Cargando…

Optimization of Mesenchymal Stromal Cell (MSC) Manufacturing Processes for a Better Therapeutic Outcome

MSCs products as well as their derived extracellular vesicles, are currently being explored as advanced biologics in cell-based therapies with high expectations for their clinical use in the next few years. In recent years, various strategies designed for improving the therapeutic potential of mesen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fernández-Santos, Maria Eugenia, Garcia-Arranz, Mariano, Andreu, Enrique J., García-Hernández, Ana Maria, López-Parra, Miriam, Villarón, Eva, Sepúlveda, Pilar, Fernández-Avilés, Francisco, García-Olmo, Damian, Prosper, Felipe, Sánchez-Guijo, Fermin, Moraleda, Jose M., Zapata, Agustin G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261977/ https://www.ncbi.nlm.nih.gov/pubmed/35812460 http://dx.doi.org/10.3389/fimmu.2022.918565

Ejemplares similares

Adipose-derived mesenchymal stromal cells for the treatment of patients with severe SARS-CoV-2 pneumonia requiring mechanical ventilation. A proof of concept study
por: Sánchez-Guijo, Fermín, et al.
Publicado: (2020)

Autologous adipose‐derived stem cells for the treatment of complex cryptoglandular perianal fistula: A randomized clinical trial with long‐term follow‐up
por: Garcia‐Arranz, Mariano, et al.
Publicado: (2019)

Exofucosylation of Adipose Mesenchymal Stromal Cells Alters Their Secretome Profile
por: García-Bernal, David, et al.
Publicado: (2020)

The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy
por: García-Bernal, David, et al.
Publicado: (2021)

Efficacy and safety of intramuscular administration of allogeneic adipose tissue derived and expanded mesenchymal stromal cells in diabetic patients with critical limb ischemia with no possibility of revascularization: study protocol for a randomized controlled double-blind phase II clinical trial (The NOMA Trial)
por: Soria-Juan, Barbara, et al.
Publicado: (2021)

MSC therapy ameliorates experimental gouty arthritis hinting an early COX-2 induction
por: Medina, Juan Pablo, et al.
Publicado: (2023)

Autologous mesenchymal stromal cells embedded with Tissucol Duo(®) for prevention of air leak after anatomical lung resection: results of a prospective phase I/II clinical trial with long-term follow-up
por: Jiménez, Marcelo F., et al.
Publicado: (2023)

Two phase I/II clinical trials for the treatment of urinary incontinence with autologous mesenchymal stem cells
por: Garcia‐Arranz, Mariano, et al.
Publicado: (2020)

Long-Term Results of a Phase I/II Clinical Trial of Autologous Mesenchymal Stem Cell Therapy for Femoral Head Osteonecrosis
por: Blanco, Juan F., et al.
Publicado: (2023)

Role of Hospital Exemption in Europe: position paper from the Spanish Advanced Therapy Network (TERAV)
por: Sánchez-Guijo, Fermín, et al.
Publicado: (2023)

Co-administration of human MSC overexpressing HIF-1α increases human CD34(+) cell engraftment in vivo
por: Preciado, Silvia, et al.
Publicado: (2021)

Autologous mesenchymal stem cell transplantation for spinal fusion: 10 years follow-up of a phase I/II clinical trial
por: Gomez-Ruiz, Victoria, et al.
Publicado: (2023)

Preliminary study on non-viral transfection of F9 (factor IX) gene by nucleofection in human adipose-derived mesenchymal stem cells
por: Olmedillas López, Susana, et al.
Publicado: (2016)

Stem cell therapy for faecal incontinence: Current state and future perspectives
por: Trébol, Jacobo, et al.
Publicado: (2018)

New method of clustering colorectal cancer patients using differential presence of exons (DPE) sequencing
por: Rubio-Mangas, David, et al.
Publicado: (2023)

Corrigendum: Cost-Effective, Safe, and Personalized Cell Therapy for Critical Limb Ischemia in Type 2 Diabetes Mellitus
por: Soria-Juan, Bárbara, et al.
Publicado: (2020)

Cost-Effective, Safe, and Personalized Cell Therapy for Critical Limb Ischemia in Type 2 Diabetes Mellitus
por: Soria-Juan, Bárbara, et al.
Publicado: (2019)

KRAS G12V Mutation Detection by Droplet Digital PCR in Circulating Cell-Free DNA of Colorectal Cancer Patients
por: Olmedillas López, Susana, et al.
Publicado: (2016)

Liquid biopsy by NGS: Differential presence of exons (DPE) is related to metastatic potential in a colon-cancer model in the rat
por: García-Olmo, Dolores C., et al.
Publicado: (2020)

Understanding CAR T cell therapy and its role in ovarian cancer and peritoneal carcinomatosis from ovarian cancer
por: Domínguez-Prieto, Víctor, et al.
Publicado: (2023)

Liquid biopsy by NGS: differential presence of exons (DPE) in cell‐free DNA reveals different patterns in metastatic and nonmetastatic colorectal cancer
por: Olmedillas‐López, Susana, et al.
Publicado: (2018)

Sequential intravenous allogeneic mesenchymal stromal cells as a potential treatment for thromboangiitis obliterans (Buerger’s disease)
por: Martin-Rufino, Jorge D., et al.
Publicado: (2018)

MSC surface markers (CD44, CD73, and CD90) can identify human MSC-derived extracellular vesicles by conventional flow cytometry
por: L. Ramos, Teresa, et al.
Publicado: (2016)

Searching for the Optimal Donor for Allogenic Adipose-Derived Stem Cells: A Comprehensive Review
por: Georgiev-Hristov, Tihomir, et al.
Publicado: (2022)

Endobronchial autologous bone marrow–mesenchymal stromal cells in idiopathic pulmonary fibrosis: a phase I trial
por: Campo, Arantza, et al.
Publicado: (2021)

Under the Hood: Understanding the Features of Mucin in Pseudomyxoma Peritonei
por: Villarejo-Campos, Pedro, et al.
Publicado: (2023)

Stem cell therapy applied for digestive anastomosis: Current state and future perspectives
por: Trébol, Jacobo, et al.
Publicado: (2022)

Mesenchymal stromal cells (MSC) from JAK2(+) myeloproliferative neoplasms differ from normal MSC and contribute to the maintenance of neoplastic hematopoiesis
por: Ramos, Teresa L., et al.
Publicado: (2017)

The effects of allogenic stem cells in a murine model of hind limb diabetic ischemic tissue
por: Álvarez García, Jesús, et al.
Publicado: (2017)

Analysis of Septin 9 Gene Hypermethylation as Follow-Up Biomarker of Colorectal Cancer Patients after Curative Surgery
por: Leon Arellano, Miguel, et al.
Publicado: (2022)

Differential presence of exons (DPE): sequencing liquid biopsy by NGS. A new method for clustering colorectal Cancer patients
por: Rubio-Mangas, David, et al.
Publicado: (2023)

Rat model of anal sphincter injury and two approaches for stem cell administration
por: Trébol, Jacobo, et al.
Publicado: (2018)

Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis
por: Lamo-Espinosa, José María, et al.
Publicado: (2021)

Autologous mesenchymal stromal cells embedded in tricalcium phosphate for posterolateral spinal fusion: results of a prospective phase I/II clinical trial with long-term follow-up
por: Blanco, Juan F., et al.
Publicado: (2019)

Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: long-term follow up of a multicenter randomized controlled clinical trial (phase I/II)
por: Lamo-Espinosa, José María, et al.
Publicado: (2018)

The role of mucin cell-free DNA detection as a new marker for the study of acellular pseudomyxoma peritonei of appendicular origin by liquid biopsy
por: García-Olmo, Damián, et al.
Publicado: (2020)

Editorial: Next generation MSC therapy manufacturing, potency and mechanism of action analysis
por: Chinnadurai, Raghavan, et al.
Publicado: (2023)

Therapeutic Effects of hMAPC and hMSC Transplantation after Stroke in Mice
por: Mora-Lee, Silvia, et al.
Publicado: (2012)

Main histological parameters to be evaluated in an experimental model of myocardial infarct treated by stem cells on pigs
por: García Gómez-Heras, Soledad, et al.
Publicado: (2019)

Chemical Scalpel: An Experimental Collagenase-Based Treatment for Peritoneal Adhesions
por: Barambio, Javier, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5v1dgnqu8km4cd5gqrp12ul2jv