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Central nervous system depressant activity of Jatamansi (Nardostachys jatamansi DC.) rhizome

BACKGROUND: Sleep disorders have a comparatively high prevalence worldwide and create a burden on the health system. Pharmacological agents used for insomnia are associated with considerable side effects. Therefore, searching for safe and effective agents from plant-based natural sources is a worthy...

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Autores principales: Panara, Kalpesh, Nariya, Mukeshkumar, Karra, Nishteswar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261992/
https://www.ncbi.nlm.nih.gov/pubmed/35813358
http://dx.doi.org/10.4103/ayu.AYU_251_20
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author Panara, Kalpesh
Nariya, Mukeshkumar
Karra, Nishteswar
author_facet Panara, Kalpesh
Nariya, Mukeshkumar
Karra, Nishteswar
author_sort Panara, Kalpesh
collection PubMed
description BACKGROUND: Sleep disorders have a comparatively high prevalence worldwide and create a burden on the health system. Pharmacological agents used for insomnia are associated with considerable side effects. Therefore, searching for safe and effective agents from plant-based natural sources is a worthy effort. Jatamansi (Nardostachys jatamansi DC.) rhizome has been recommended for insomnia and mental conditions in the Indian system of medicine. AIM: This study aimed to determine central nervous system (CNS) depressant activity of Jatamansi (N. jatamansi) rhizome on experimental animals. MATERIALS AND METHODS: Gross behavior study and open field test (locomotor activity) were performed by using Charle’s foster albino rats whereas rota-rod test and pentobarbital-induced sleep test in Swiss albino mice. Animals were divided into 3 groups (per model) having six animals in each group. The control group was treated with water, the standard group with diazepam and the test drug with powder of N. Jatamansi rhizome. Results were calculated by one-way ANOVA and post hoc test with P < 0.05 as significant. RESULTS: Data suggested that Jatamansi did not produce a significant effect on the behavior of animals. It reduced the horizontal activity significantly (P < 0.001) in the open field apparatus. The test drug did not show a significant decrease in latency of fall-off time in rota-rod performance in mice. Still, it exerted a significant effect by a reduction in latency of onset of sleep (P < 0.01) and also extended the total duration of sleep (P < 0.05) in albino mice in comparison to the control group. CONCLUSION: This study shows that Jatamansi rhizome powder possesses CNS depressant activity without affecting gross behavior and muscle coordination in rats.
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spelling pubmed-92619922022-07-08 Central nervous system depressant activity of Jatamansi (Nardostachys jatamansi DC.) rhizome Panara, Kalpesh Nariya, Mukeshkumar Karra, Nishteswar Ayu Original Article BACKGROUND: Sleep disorders have a comparatively high prevalence worldwide and create a burden on the health system. Pharmacological agents used for insomnia are associated with considerable side effects. Therefore, searching for safe and effective agents from plant-based natural sources is a worthy effort. Jatamansi (Nardostachys jatamansi DC.) rhizome has been recommended for insomnia and mental conditions in the Indian system of medicine. AIM: This study aimed to determine central nervous system (CNS) depressant activity of Jatamansi (N. jatamansi) rhizome on experimental animals. MATERIALS AND METHODS: Gross behavior study and open field test (locomotor activity) were performed by using Charle’s foster albino rats whereas rota-rod test and pentobarbital-induced sleep test in Swiss albino mice. Animals were divided into 3 groups (per model) having six animals in each group. The control group was treated with water, the standard group with diazepam and the test drug with powder of N. Jatamansi rhizome. Results were calculated by one-way ANOVA and post hoc test with P < 0.05 as significant. RESULTS: Data suggested that Jatamansi did not produce a significant effect on the behavior of animals. It reduced the horizontal activity significantly (P < 0.001) in the open field apparatus. The test drug did not show a significant decrease in latency of fall-off time in rota-rod performance in mice. Still, it exerted a significant effect by a reduction in latency of onset of sleep (P < 0.01) and also extended the total duration of sleep (P < 0.05) in albino mice in comparison to the control group. CONCLUSION: This study shows that Jatamansi rhizome powder possesses CNS depressant activity without affecting gross behavior and muscle coordination in rats. Wolters Kluwer - Medknow 2020 2022-06-03 /pmc/articles/PMC9261992/ /pubmed/35813358 http://dx.doi.org/10.4103/ayu.AYU_251_20 Text en Copyright: © 2022 AYU (An International Quarterly Journal of Research in Ayurveda) https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Panara, Kalpesh
Nariya, Mukeshkumar
Karra, Nishteswar
Central nervous system depressant activity of Jatamansi (Nardostachys jatamansi DC.) rhizome
title Central nervous system depressant activity of Jatamansi (Nardostachys jatamansi DC.) rhizome
title_full Central nervous system depressant activity of Jatamansi (Nardostachys jatamansi DC.) rhizome
title_fullStr Central nervous system depressant activity of Jatamansi (Nardostachys jatamansi DC.) rhizome
title_full_unstemmed Central nervous system depressant activity of Jatamansi (Nardostachys jatamansi DC.) rhizome
title_short Central nervous system depressant activity of Jatamansi (Nardostachys jatamansi DC.) rhizome
title_sort central nervous system depressant activity of jatamansi (nardostachys jatamansi dc.) rhizome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9261992/
https://www.ncbi.nlm.nih.gov/pubmed/35813358
http://dx.doi.org/10.4103/ayu.AYU_251_20
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