Adaptogenic and immunomodulatory activity of Virgozest Avaleha – An ayurvedic proprietary formulation

INTRODUCTION: Rasayana (rejuvenator) or adaptogenic drugs have been proved to produce the complete potential to prevent diseases and degenerative changes that leads to diseases and promote longevity by providing strength and immunity. Virgozest Avaleha is a poly-herbal formulation claimed to serve as adaptogenic, and immunomodulatory, as a health tonic, enriched with dry fruits, and ingredients containing natural supplements of Vitamin E and proteins. AIM: To evaluate the adaptogenic activity and humoral immune activity of virgozest Avaleha in Wistar albino rats. MATERIALS AND METHODS: Virgozest Avaleha was evaluated for adaptogenic activity against swimming stress-induced changes and hypothermia in albino rats. The humoral immune activity of virgozest Avaleha was evaluated against sheep red blood cells (SRBCs)-induced response in albino rats with the inclusion of cyclophosphamide as immune suppressant agent. RESULTS: In adaptogenic activity, virgozest Avaleha (450 and 900 mg/kg) exhibited an increase in physical activity, decrease in stress-induced hypothermia, and serum cortisol level when compared to the stress control group of albino rats. In humoral immune activity, virgozest Avaleha reversed the effects of cyclophosphamide-induced adverse changes on spleen and lymph node, and produced a significant increase in serum antibody titer in SRBCs-sensitized rats. CONCLUSION: The present study concluded that virgozest Avaleha has adaptogenic and humoral immune activity in Wistar albino rats, which may suggest the Rasayana like properties of Ayurvedic formulation.