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Research on the Mechanism and Prevention of Hypertension Caused by Apatinib Through the RhoA/ROCK Signaling Pathway in a Mouse Model of Gastric Cancer

Hypertension is one of the main adverse effects of antiangiogenic tumor drugs and thus limits their application. The mechanism of hypertension caused by tyrosine kinase inhibitors (TKIs) targeting vascular endothelial growth factors is mainly related to inhibition of the nitric oxide (NO) pathway an...

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Detalles Bibliográficos
Autores principales:	Wang, Wenjuan, Li, Caie, Zhuang, Chenchen, Zhang, Haodong, Wang, Qiongying, Fan, Xin, Qi, Miaomiao, Sun, Runmin, Yu, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262125/ https://www.ncbi.nlm.nih.gov/pubmed/35811723 http://dx.doi.org/10.3389/fcvm.2022.873829

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