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Geriatric nutritional risk index as a prognostic factor in patients with recurrent pancreatic cancer

The aim of this study is to investigate the prognostic significance of geriatric nutritional risk index (GNRI) at the time of recurrence in patients with recurrent pancreatic cancer, and the relationship between GNRI and skeletal muscle mass for survival outcomes after recurrence. This study enrolle...

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Autores principales: Sakamoto, Teruhisa, Makinoya, Masahiro, Sunaguchi, Teppei, Goto, Keisuke, Morimoto, Masaki, Murakami, Yuki, Miyatani, Kozo, Hanaki, Takehiko, Shishido, Yuji, Kihara, Kyoichi, Matsunaga, Tomoyuki, Yamamoto, Manabu, Tokuyasu, Naruo, Fujiwara, Yoshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262175/
https://www.ncbi.nlm.nih.gov/pubmed/35797279
http://dx.doi.org/10.1371/journal.pone.0271073
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author Sakamoto, Teruhisa
Makinoya, Masahiro
Sunaguchi, Teppei
Goto, Keisuke
Morimoto, Masaki
Murakami, Yuki
Miyatani, Kozo
Hanaki, Takehiko
Shishido, Yuji
Kihara, Kyoichi
Matsunaga, Tomoyuki
Yamamoto, Manabu
Tokuyasu, Naruo
Fujiwara, Yoshiyuki
author_facet Sakamoto, Teruhisa
Makinoya, Masahiro
Sunaguchi, Teppei
Goto, Keisuke
Morimoto, Masaki
Murakami, Yuki
Miyatani, Kozo
Hanaki, Takehiko
Shishido, Yuji
Kihara, Kyoichi
Matsunaga, Tomoyuki
Yamamoto, Manabu
Tokuyasu, Naruo
Fujiwara, Yoshiyuki
author_sort Sakamoto, Teruhisa
collection PubMed
description The aim of this study is to investigate the prognostic significance of geriatric nutritional risk index (GNRI) at the time of recurrence in patients with recurrent pancreatic cancer, and the relationship between GNRI and skeletal muscle mass for survival outcomes after recurrence. This study enrolled 77 patients who developed postoperative recurrence. The skeletal muscle mass index (SMI) was used in this study. The patients were divided into a high-GNRI group (n = 36) and a low-GNRI group (n = 41) for the GNRI, and were divided into a high-SMI group (n = 38) and a low-SMI group (n = 39) for SMI. The 2-year post-recurrence overall survival of patients in the high-GNRI group was significantly longer than that of patients in the low-GNRI group (P = 0.001). No significant difference for the 2-year post-recurrence OS curves between the high-SMI group and the low-SMI group was observed (P = 0.125). Upon stratifying the patients with high GNRI or low GNRI according to SMI, There was no significant difference in the 2-year post-recurrence OS curves between the patients with both high GNRI and high SMI and the patients with high GNRI and low SMI (P = 0.399). Similarly, There was no significant difference in the 2-year post-recurrence OS curves between the patients with low GNRI and high SMI and the patients with both low GNRI and low SMI (P = 0.256). Multivariate analysis revealed that the GNRI at the time of recurrence was an independent prognostic risk factor in patients with recurrent pancreatic cancer (P = 0.019). The GNRI at the time of recurrence is useful for predicting the prognosis in patients with recurrence pancreatic cancer. Skeletal muscle mass at the time of recurrence is not contributed to predict post-recurrence survival of patients with recurrent pancreatic cancer.
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spelling pubmed-92621752022-07-08 Geriatric nutritional risk index as a prognostic factor in patients with recurrent pancreatic cancer Sakamoto, Teruhisa Makinoya, Masahiro Sunaguchi, Teppei Goto, Keisuke Morimoto, Masaki Murakami, Yuki Miyatani, Kozo Hanaki, Takehiko Shishido, Yuji Kihara, Kyoichi Matsunaga, Tomoyuki Yamamoto, Manabu Tokuyasu, Naruo Fujiwara, Yoshiyuki PLoS One Research Article The aim of this study is to investigate the prognostic significance of geriatric nutritional risk index (GNRI) at the time of recurrence in patients with recurrent pancreatic cancer, and the relationship between GNRI and skeletal muscle mass for survival outcomes after recurrence. This study enrolled 77 patients who developed postoperative recurrence. The skeletal muscle mass index (SMI) was used in this study. The patients were divided into a high-GNRI group (n = 36) and a low-GNRI group (n = 41) for the GNRI, and were divided into a high-SMI group (n = 38) and a low-SMI group (n = 39) for SMI. The 2-year post-recurrence overall survival of patients in the high-GNRI group was significantly longer than that of patients in the low-GNRI group (P = 0.001). No significant difference for the 2-year post-recurrence OS curves between the high-SMI group and the low-SMI group was observed (P = 0.125). Upon stratifying the patients with high GNRI or low GNRI according to SMI, There was no significant difference in the 2-year post-recurrence OS curves between the patients with both high GNRI and high SMI and the patients with high GNRI and low SMI (P = 0.399). Similarly, There was no significant difference in the 2-year post-recurrence OS curves between the patients with low GNRI and high SMI and the patients with both low GNRI and low SMI (P = 0.256). Multivariate analysis revealed that the GNRI at the time of recurrence was an independent prognostic risk factor in patients with recurrent pancreatic cancer (P = 0.019). The GNRI at the time of recurrence is useful for predicting the prognosis in patients with recurrence pancreatic cancer. Skeletal muscle mass at the time of recurrence is not contributed to predict post-recurrence survival of patients with recurrent pancreatic cancer. Public Library of Science 2022-07-07 /pmc/articles/PMC9262175/ /pubmed/35797279 http://dx.doi.org/10.1371/journal.pone.0271073 Text en © 2022 Sakamoto et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sakamoto, Teruhisa
Makinoya, Masahiro
Sunaguchi, Teppei
Goto, Keisuke
Morimoto, Masaki
Murakami, Yuki
Miyatani, Kozo
Hanaki, Takehiko
Shishido, Yuji
Kihara, Kyoichi
Matsunaga, Tomoyuki
Yamamoto, Manabu
Tokuyasu, Naruo
Fujiwara, Yoshiyuki
Geriatric nutritional risk index as a prognostic factor in patients with recurrent pancreatic cancer
title Geriatric nutritional risk index as a prognostic factor in patients with recurrent pancreatic cancer
title_full Geriatric nutritional risk index as a prognostic factor in patients with recurrent pancreatic cancer
title_fullStr Geriatric nutritional risk index as a prognostic factor in patients with recurrent pancreatic cancer
title_full_unstemmed Geriatric nutritional risk index as a prognostic factor in patients with recurrent pancreatic cancer
title_short Geriatric nutritional risk index as a prognostic factor in patients with recurrent pancreatic cancer
title_sort geriatric nutritional risk index as a prognostic factor in patients with recurrent pancreatic cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262175/
https://www.ncbi.nlm.nih.gov/pubmed/35797279
http://dx.doi.org/10.1371/journal.pone.0271073
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