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Quantitative CT lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children

The purpose of this study is to evaluate the quantitative diagnostic performance of computed tomography (CT) densitometry in pediatric patients with bronchiolitis obliterans (BO). We measured the mean lung density (MLD) and represented the difference of MLD in inspiratory and expiratory phases (MLDD...

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Autores principales: Lee, Hye Jin, Kim, Seong Koo, Lee, Jae Wook, Im, Soo Ah, Chung, Nack-Gyun, Cho, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262182/
https://www.ncbi.nlm.nih.gov/pubmed/35797398
http://dx.doi.org/10.1371/journal.pone.0271135
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author Lee, Hye Jin
Kim, Seong Koo
Lee, Jae Wook
Im, Soo Ah
Chung, Nack-Gyun
Cho, Bin
author_facet Lee, Hye Jin
Kim, Seong Koo
Lee, Jae Wook
Im, Soo Ah
Chung, Nack-Gyun
Cho, Bin
author_sort Lee, Hye Jin
collection PubMed
description The purpose of this study is to evaluate the quantitative diagnostic performance of computed tomography (CT) densitometry in pediatric patients with bronchiolitis obliterans (BO). We measured the mean lung density (MLD) and represented the difference of MLD in inspiratory and expiratory phases (MLDD), the ratio of the MLD (E/I MLD), and the relative volume percentage of lung density at 50-Hounsfield unit (HU) interval threshold (E600 to E950). We calculated the sensitivity, specificity, and diagnostic accuracy of the lung density indices for the diagnosis of BO. A total of 81 patients, including 51 patients with BO and 30 controls, were included in this study. In the BO patients, expiratory (EXP) MLD and MLDD were significantly lower, and E/I MLD and expiratory low attenuation areas below the threshold of −850 HU to −950 HU (E850, E900, and E950) were statistically significantly higher than controls. Multivariate logistic regression analysis showed that MLDD (odds ratio [OR] = 0.98, p < .001), E/I MLD (OR = 1.39, p < .001), and E850 to E950 were significant densitometry parameters for BO diagnosis. In a receiver-operating characteristic analysis, E900 (cutoff, 1.4%; AUC = 0.920), E/I MLD (cutoff, 0.87; AUC = 0.887), and MLDD (cutoff, 109 HU; AUC = 0.867) showed high accuracy for the diagnosis of BO. In conclusion, the lung CT densitometry can serve as a quantitative marker providing additional indications of expiratory airflow limitation in pediatric patients with BO.
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spelling pubmed-92621822022-07-08 Quantitative CT lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children Lee, Hye Jin Kim, Seong Koo Lee, Jae Wook Im, Soo Ah Chung, Nack-Gyun Cho, Bin PLoS One Research Article The purpose of this study is to evaluate the quantitative diagnostic performance of computed tomography (CT) densitometry in pediatric patients with bronchiolitis obliterans (BO). We measured the mean lung density (MLD) and represented the difference of MLD in inspiratory and expiratory phases (MLDD), the ratio of the MLD (E/I MLD), and the relative volume percentage of lung density at 50-Hounsfield unit (HU) interval threshold (E600 to E950). We calculated the sensitivity, specificity, and diagnostic accuracy of the lung density indices for the diagnosis of BO. A total of 81 patients, including 51 patients with BO and 30 controls, were included in this study. In the BO patients, expiratory (EXP) MLD and MLDD were significantly lower, and E/I MLD and expiratory low attenuation areas below the threshold of −850 HU to −950 HU (E850, E900, and E950) were statistically significantly higher than controls. Multivariate logistic regression analysis showed that MLDD (odds ratio [OR] = 0.98, p < .001), E/I MLD (OR = 1.39, p < .001), and E850 to E950 were significant densitometry parameters for BO diagnosis. In a receiver-operating characteristic analysis, E900 (cutoff, 1.4%; AUC = 0.920), E/I MLD (cutoff, 0.87; AUC = 0.887), and MLDD (cutoff, 109 HU; AUC = 0.867) showed high accuracy for the diagnosis of BO. In conclusion, the lung CT densitometry can serve as a quantitative marker providing additional indications of expiratory airflow limitation in pediatric patients with BO. Public Library of Science 2022-07-07 /pmc/articles/PMC9262182/ /pubmed/35797398 http://dx.doi.org/10.1371/journal.pone.0271135 Text en © 2022 Lee et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lee, Hye Jin
Kim, Seong Koo
Lee, Jae Wook
Im, Soo Ah
Chung, Nack-Gyun
Cho, Bin
Quantitative CT lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children
title Quantitative CT lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children
title_full Quantitative CT lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children
title_fullStr Quantitative CT lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children
title_full_unstemmed Quantitative CT lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children
title_short Quantitative CT lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children
title_sort quantitative ct lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262182/
https://www.ncbi.nlm.nih.gov/pubmed/35797398
http://dx.doi.org/10.1371/journal.pone.0271135
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