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Quantitative CT lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children
The purpose of this study is to evaluate the quantitative diagnostic performance of computed tomography (CT) densitometry in pediatric patients with bronchiolitis obliterans (BO). We measured the mean lung density (MLD) and represented the difference of MLD in inspiratory and expiratory phases (MLDD...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262182/ https://www.ncbi.nlm.nih.gov/pubmed/35797398 http://dx.doi.org/10.1371/journal.pone.0271135 |
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author | Lee, Hye Jin Kim, Seong Koo Lee, Jae Wook Im, Soo Ah Chung, Nack-Gyun Cho, Bin |
author_facet | Lee, Hye Jin Kim, Seong Koo Lee, Jae Wook Im, Soo Ah Chung, Nack-Gyun Cho, Bin |
author_sort | Lee, Hye Jin |
collection | PubMed |
description | The purpose of this study is to evaluate the quantitative diagnostic performance of computed tomography (CT) densitometry in pediatric patients with bronchiolitis obliterans (BO). We measured the mean lung density (MLD) and represented the difference of MLD in inspiratory and expiratory phases (MLDD), the ratio of the MLD (E/I MLD), and the relative volume percentage of lung density at 50-Hounsfield unit (HU) interval threshold (E600 to E950). We calculated the sensitivity, specificity, and diagnostic accuracy of the lung density indices for the diagnosis of BO. A total of 81 patients, including 51 patients with BO and 30 controls, were included in this study. In the BO patients, expiratory (EXP) MLD and MLDD were significantly lower, and E/I MLD and expiratory low attenuation areas below the threshold of −850 HU to −950 HU (E850, E900, and E950) were statistically significantly higher than controls. Multivariate logistic regression analysis showed that MLDD (odds ratio [OR] = 0.98, p < .001), E/I MLD (OR = 1.39, p < .001), and E850 to E950 were significant densitometry parameters for BO diagnosis. In a receiver-operating characteristic analysis, E900 (cutoff, 1.4%; AUC = 0.920), E/I MLD (cutoff, 0.87; AUC = 0.887), and MLDD (cutoff, 109 HU; AUC = 0.867) showed high accuracy for the diagnosis of BO. In conclusion, the lung CT densitometry can serve as a quantitative marker providing additional indications of expiratory airflow limitation in pediatric patients with BO. |
format | Online Article Text |
id | pubmed-9262182 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-92621822022-07-08 Quantitative CT lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children Lee, Hye Jin Kim, Seong Koo Lee, Jae Wook Im, Soo Ah Chung, Nack-Gyun Cho, Bin PLoS One Research Article The purpose of this study is to evaluate the quantitative diagnostic performance of computed tomography (CT) densitometry in pediatric patients with bronchiolitis obliterans (BO). We measured the mean lung density (MLD) and represented the difference of MLD in inspiratory and expiratory phases (MLDD), the ratio of the MLD (E/I MLD), and the relative volume percentage of lung density at 50-Hounsfield unit (HU) interval threshold (E600 to E950). We calculated the sensitivity, specificity, and diagnostic accuracy of the lung density indices for the diagnosis of BO. A total of 81 patients, including 51 patients with BO and 30 controls, were included in this study. In the BO patients, expiratory (EXP) MLD and MLDD were significantly lower, and E/I MLD and expiratory low attenuation areas below the threshold of −850 HU to −950 HU (E850, E900, and E950) were statistically significantly higher than controls. Multivariate logistic regression analysis showed that MLDD (odds ratio [OR] = 0.98, p < .001), E/I MLD (OR = 1.39, p < .001), and E850 to E950 were significant densitometry parameters for BO diagnosis. In a receiver-operating characteristic analysis, E900 (cutoff, 1.4%; AUC = 0.920), E/I MLD (cutoff, 0.87; AUC = 0.887), and MLDD (cutoff, 109 HU; AUC = 0.867) showed high accuracy for the diagnosis of BO. In conclusion, the lung CT densitometry can serve as a quantitative marker providing additional indications of expiratory airflow limitation in pediatric patients with BO. Public Library of Science 2022-07-07 /pmc/articles/PMC9262182/ /pubmed/35797398 http://dx.doi.org/10.1371/journal.pone.0271135 Text en © 2022 Lee et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Lee, Hye Jin Kim, Seong Koo Lee, Jae Wook Im, Soo Ah Chung, Nack-Gyun Cho, Bin Quantitative CT lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children |
title | Quantitative CT lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children |
title_full | Quantitative CT lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children |
title_fullStr | Quantitative CT lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children |
title_full_unstemmed | Quantitative CT lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children |
title_short | Quantitative CT lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children |
title_sort | quantitative ct lung densitometry as an obstructive marker for the diagnosis of bronchiolitis obliterans in children |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262182/ https://www.ncbi.nlm.nih.gov/pubmed/35797398 http://dx.doi.org/10.1371/journal.pone.0271135 |
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