Cargando…

Evaluating indirect genetic effects of siblings using singletons

Estimating effects of parental and sibling genotypes (indirect genetic effects) can provide insight into how the family environment influences phenotypic variation. There is growing molecular genetic evidence for effects of parental phenotypes on their offspring (e.g. parental educational attainment...

Descripción completa

Detalles Bibliográficos
Autores principales:	Howe, Laurence J., Evans, David M., Hemani, Gibran, Davey Smith, George, Davies, Neil M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262210/ https://www.ncbi.nlm.nih.gov/pubmed/35797272 http://dx.doi.org/10.1371/journal.pgen.1010247

Ejemplares similares

Population phenomena inflate genetic associations of complex social traits
por: Morris, Tim T., et al.
Publicado: (2020)

Genetic evidence for assortative mating on alcohol consumption in the UK Biobank
por: Howe, Laurence J., et al.
Publicado: (2019)

Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?
por: Lawson, Daniel John, et al.
Publicado: (2019)

Mendelian randomization: genetic anchors for causal inference in epidemiological studies
por: Davey Smith, George, et al.
Publicado: (2014)

Assortative mating and within-spouse pair comparisons
por: Howe, Laurence J., et al.
Publicado: (2021)

The role of common genetic variation in educational attainment and income: evidence from the National Child Development Study
por: Davies, Neil M., et al.
Publicado: (2015)

Evaluating the potential role of pleiotropy in Mendelian randomization studies
por: Hemani, Gibran, et al.
Publicado: (2018)

Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique
por: Hartwig, Fernando Pires, et al.
Publicado: (2016)

Overweight in singletons compared to children with siblings: the IDEFICS study
por: Hunsberger, M, et al.
Publicado: (2012)

Overweight in singletons compared to children with siblings: the IDEFICS study
por: Hunsberger, M, et al.
Publicado: (2012)

Orienting the causal relationship between imprecisely measured traits using GWAS summary data
por: Hemani, Gibran, et al.
Publicado: (2017)

Correction: Orienting the causal relationship between imprecisely measured traits using GWAS summary data
por: Hemani, Gibran, et al.
Publicado: (2017)

Evaluating shared genetic influences on nonsyndromic cleft lip/palate and oropharyngeal neoplasms
por: Howe, Laurence J., et al.
Publicado: (2020)

Partitioning Phenotypic Variance Due to Parent-of-Origin Effects Using Genomic Relatedness Matrices
por: Laurin, Charles, et al.
Publicado: (2017)

Estimating indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half sibling pairs
por: Hwang, Liang-Dar, et al.
Publicado: (2020)

Invited Commentary: Detecting Individual and Global Horizontal Pleiotropy in Mendelian Randomization—A Job for the Humble Heterogeneity Statistic?
por: Bowden, Jack, et al.
Publicado: (2018)

A comparison of perinatal outcomes following fresh blastocyst or cleavage stage embryo transfer in singletons and twins and between singleton siblings
por: Raja, Edwin-Amalraj, et al.
Publicado: (2023)

Causal inference for heritable phenotypic risk factors using heterogeneous genetic instruments
por: Wang, Jingshu, et al.
Publicado: (2021)

The use of negative control outcomes in Mendelian randomization to detect potential population stratification
por: Sanderson, Eleanor, et al.
Publicado: (2021)

Using the MR-Base platform to investigate risk factors and drug targets for thousands of phenotypes
por: Walker, Venexia M, et al.
Publicado: (2019)

Evaluating and implementing block jackknife resampling Mendelian randomization to mitigate bias induced by overlapping samples
por: Fang, Si, et al.
Publicado: (2022)

Maternal Smoking During Pregnancy and the Risk of Psychiatric Morbidity in Singleton Sibling Pairs
por: Ekblad, Mikael, et al.
Publicado: (2017)

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome
por: Richardson, Tom G, et al.
Publicado: (2019)

Interpreting Mendelian-randomization estimates of the effects of categorical exposures such as disease status and educational attainment
por: Howe, Laurence J, et al.
Publicado: (2021)

Recent Developments in Mendelian Randomization Studies
por: Zheng, Jie, et al.
Publicado: (2017)

Genetic Analyses of Common Infections in the Avon Longitudinal Study of Parents and Children Cohort
por: Chong, Amanda H. W., et al.
Publicado: (2021)

Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk
por: Richardson, Tom G., et al.
Publicado: (2017)

Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study
por: Higbee, Daniel H., et al.
Publicado: (2021)

Review and further developments in statistical corrections for Winner’s Curse in genetic association studies
por: Forde, Amanda, et al.
Publicado: (2023)

A transcriptome-wide Mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome
por: Richardson, Tom G., et al.
Publicado: (2020)

Can education be personalised using pupils’ genetic data?
por: Morris, Tim T, et al.
Publicado: (2020)

Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants
por: Borges, Maria Carolina, et al.
Publicado: (2022)

Education, intelligence and Alzheimer’s disease: evidence from a multivariable two-sample Mendelian randomization study
por: Anderson, Emma L, et al.
Publicado: (2020)

Singletons and superstrings
por: Günaydin, M, et al.
Publicado: (1986)

Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease
por: Richardson, Tom G, et al.
Publicado: (2018)

Estimating Marginal Healthcare Costs Using Genetic Variants as Instrumental Variables: Mendelian Randomization in Economic Evaluation
por: Dixon, Padraig, et al.
Publicado: (2016)

Indirect Genetic Effects of ADIPOQ Variants on Lipid Levels in a Sibling Study of a Rural Chinese Population
por: Zhou, Zechen, et al.
Publicado: (2022)

Schizophrenia risk and reproductive success: a Mendelian randomization study
por: Lawn, Rebecca B., et al.
Publicado: (2019)

Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology
por: Howe, Laurence J., et al.
Publicado: (2018)

Systematic identification of genetic influences on methylation across the human life course
por: Gaunt, Tom R., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_oq715rlac3tp3tjglroncouep1