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Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches
Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer....
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262248/ https://www.ncbi.nlm.nih.gov/pubmed/35814435 http://dx.doi.org/10.3389/fonc.2022.891652 |
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author | Emran, Talha Bin Shahriar, Asif Mahmud, Aar Rafi Rahman, Tanjilur Abir, Mehedy Hasan Siddiquee, Mohd. Faijanur - Rob Ahmed, Hossain Rahman, Nova Nainu, Firzan Wahyudin, Elly Mitra, Saikat Dhama, Kuldeep Habiballah, Mahmoud M. Haque, Shafiul Islam, Ariful Hassan, Mohammad Mahmudul |
author_facet | Emran, Talha Bin Shahriar, Asif Mahmud, Aar Rafi Rahman, Tanjilur Abir, Mehedy Hasan Siddiquee, Mohd. Faijanur - Rob Ahmed, Hossain Rahman, Nova Nainu, Firzan Wahyudin, Elly Mitra, Saikat Dhama, Kuldeep Habiballah, Mahmoud M. Haque, Shafiul Islam, Ariful Hassan, Mohammad Mahmudul |
author_sort | Emran, Talha Bin |
collection | PubMed |
description | Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer. This review describes the known MDR mechanisms in cancer cells and discusses ongoing laboratory approaches and novel therapeutic strategies that aim to inhibit, circumvent, or reverse MDR development in various cancer types. In this review, we discuss both intrinsic and acquired drug resistance, in addition to highlighting hypoxia- and autophagy-mediated drug resistance mechanisms. Several factors, including individual genetic differences, such as mutations, altered epigenetics, enhanced drug efflux, cell death inhibition, and various other molecular and cellular mechanisms, are responsible for the development of resistance against anticancer agents. Drug resistance can also depend on cellular autophagic and hypoxic status. The expression of drug-resistant genes and the regulatory mechanisms that determine drug resistance are also discussed. Methods to circumvent MDR, including immunoprevention, the use of microparticles and nanomedicine might result in better strategies for fighting cancer. |
format | Online Article Text |
id | pubmed-9262248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92622482022-07-08 Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches Emran, Talha Bin Shahriar, Asif Mahmud, Aar Rafi Rahman, Tanjilur Abir, Mehedy Hasan Siddiquee, Mohd. Faijanur - Rob Ahmed, Hossain Rahman, Nova Nainu, Firzan Wahyudin, Elly Mitra, Saikat Dhama, Kuldeep Habiballah, Mahmoud M. Haque, Shafiul Islam, Ariful Hassan, Mohammad Mahmudul Front Oncol Oncology Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer. This review describes the known MDR mechanisms in cancer cells and discusses ongoing laboratory approaches and novel therapeutic strategies that aim to inhibit, circumvent, or reverse MDR development in various cancer types. In this review, we discuss both intrinsic and acquired drug resistance, in addition to highlighting hypoxia- and autophagy-mediated drug resistance mechanisms. Several factors, including individual genetic differences, such as mutations, altered epigenetics, enhanced drug efflux, cell death inhibition, and various other molecular and cellular mechanisms, are responsible for the development of resistance against anticancer agents. Drug resistance can also depend on cellular autophagic and hypoxic status. The expression of drug-resistant genes and the regulatory mechanisms that determine drug resistance are also discussed. Methods to circumvent MDR, including immunoprevention, the use of microparticles and nanomedicine might result in better strategies for fighting cancer. Frontiers Media S.A. 2022-06-23 /pmc/articles/PMC9262248/ /pubmed/35814435 http://dx.doi.org/10.3389/fonc.2022.891652 Text en Copyright © 2022 Emran, Shahriar, Mahmud, Rahman, Abir, Siddiquee, Ahmed, Rahman, Nainu, Wahyudin, Mitra, Dhama, Habiballah, Haque, Islam and Hassan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Emran, Talha Bin Shahriar, Asif Mahmud, Aar Rafi Rahman, Tanjilur Abir, Mehedy Hasan Siddiquee, Mohd. Faijanur - Rob Ahmed, Hossain Rahman, Nova Nainu, Firzan Wahyudin, Elly Mitra, Saikat Dhama, Kuldeep Habiballah, Mahmoud M. Haque, Shafiul Islam, Ariful Hassan, Mohammad Mahmudul Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches |
title | Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches |
title_full | Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches |
title_fullStr | Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches |
title_full_unstemmed | Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches |
title_short | Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches |
title_sort | multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262248/ https://www.ncbi.nlm.nih.gov/pubmed/35814435 http://dx.doi.org/10.3389/fonc.2022.891652 |
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