Cargando…

Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches

Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer....

Descripción completa

Detalles Bibliográficos
Autores principales: Emran, Talha Bin, Shahriar, Asif, Mahmud, Aar Rafi, Rahman, Tanjilur, Abir, Mehedy Hasan, Siddiquee, Mohd. Faijanur - Rob, Ahmed, Hossain, Rahman, Nova, Nainu, Firzan, Wahyudin, Elly, Mitra, Saikat, Dhama, Kuldeep, Habiballah, Mahmoud M., Haque, Shafiul, Islam, Ariful, Hassan, Mohammad Mahmudul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262248/
https://www.ncbi.nlm.nih.gov/pubmed/35814435
http://dx.doi.org/10.3389/fonc.2022.891652
_version_ 1784742451808829440
author Emran, Talha Bin
Shahriar, Asif
Mahmud, Aar Rafi
Rahman, Tanjilur
Abir, Mehedy Hasan
Siddiquee, Mohd. Faijanur - Rob
Ahmed, Hossain
Rahman, Nova
Nainu, Firzan
Wahyudin, Elly
Mitra, Saikat
Dhama, Kuldeep
Habiballah, Mahmoud M.
Haque, Shafiul
Islam, Ariful
Hassan, Mohammad Mahmudul
author_facet Emran, Talha Bin
Shahriar, Asif
Mahmud, Aar Rafi
Rahman, Tanjilur
Abir, Mehedy Hasan
Siddiquee, Mohd. Faijanur - Rob
Ahmed, Hossain
Rahman, Nova
Nainu, Firzan
Wahyudin, Elly
Mitra, Saikat
Dhama, Kuldeep
Habiballah, Mahmoud M.
Haque, Shafiul
Islam, Ariful
Hassan, Mohammad Mahmudul
author_sort Emran, Talha Bin
collection PubMed
description Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer. This review describes the known MDR mechanisms in cancer cells and discusses ongoing laboratory approaches and novel therapeutic strategies that aim to inhibit, circumvent, or reverse MDR development in various cancer types. In this review, we discuss both intrinsic and acquired drug resistance, in addition to highlighting hypoxia- and autophagy-mediated drug resistance mechanisms. Several factors, including individual genetic differences, such as mutations, altered epigenetics, enhanced drug efflux, cell death inhibition, and various other molecular and cellular mechanisms, are responsible for the development of resistance against anticancer agents. Drug resistance can also depend on cellular autophagic and hypoxic status. The expression of drug-resistant genes and the regulatory mechanisms that determine drug resistance are also discussed. Methods to circumvent MDR, including immunoprevention, the use of microparticles and nanomedicine might result in better strategies for fighting cancer.
format Online
Article
Text
id pubmed-9262248
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92622482022-07-08 Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches Emran, Talha Bin Shahriar, Asif Mahmud, Aar Rafi Rahman, Tanjilur Abir, Mehedy Hasan Siddiquee, Mohd. Faijanur - Rob Ahmed, Hossain Rahman, Nova Nainu, Firzan Wahyudin, Elly Mitra, Saikat Dhama, Kuldeep Habiballah, Mahmoud M. Haque, Shafiul Islam, Ariful Hassan, Mohammad Mahmudul Front Oncol Oncology Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer. This review describes the known MDR mechanisms in cancer cells and discusses ongoing laboratory approaches and novel therapeutic strategies that aim to inhibit, circumvent, or reverse MDR development in various cancer types. In this review, we discuss both intrinsic and acquired drug resistance, in addition to highlighting hypoxia- and autophagy-mediated drug resistance mechanisms. Several factors, including individual genetic differences, such as mutations, altered epigenetics, enhanced drug efflux, cell death inhibition, and various other molecular and cellular mechanisms, are responsible for the development of resistance against anticancer agents. Drug resistance can also depend on cellular autophagic and hypoxic status. The expression of drug-resistant genes and the regulatory mechanisms that determine drug resistance are also discussed. Methods to circumvent MDR, including immunoprevention, the use of microparticles and nanomedicine might result in better strategies for fighting cancer. Frontiers Media S.A. 2022-06-23 /pmc/articles/PMC9262248/ /pubmed/35814435 http://dx.doi.org/10.3389/fonc.2022.891652 Text en Copyright © 2022 Emran, Shahriar, Mahmud, Rahman, Abir, Siddiquee, Ahmed, Rahman, Nainu, Wahyudin, Mitra, Dhama, Habiballah, Haque, Islam and Hassan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Emran, Talha Bin
Shahriar, Asif
Mahmud, Aar Rafi
Rahman, Tanjilur
Abir, Mehedy Hasan
Siddiquee, Mohd. Faijanur - Rob
Ahmed, Hossain
Rahman, Nova
Nainu, Firzan
Wahyudin, Elly
Mitra, Saikat
Dhama, Kuldeep
Habiballah, Mahmoud M.
Haque, Shafiul
Islam, Ariful
Hassan, Mohammad Mahmudul
Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches
title Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches
title_full Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches
title_fullStr Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches
title_full_unstemmed Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches
title_short Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches
title_sort multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262248/
https://www.ncbi.nlm.nih.gov/pubmed/35814435
http://dx.doi.org/10.3389/fonc.2022.891652
work_keys_str_mv AT emrantalhabin multidrugresistanceincancerunderstandingmolecularmechanismsimmunopreventionandtherapeuticapproaches
AT shahriarasif multidrugresistanceincancerunderstandingmolecularmechanismsimmunopreventionandtherapeuticapproaches
AT mahmudaarrafi multidrugresistanceincancerunderstandingmolecularmechanismsimmunopreventionandtherapeuticapproaches
AT rahmantanjilur multidrugresistanceincancerunderstandingmolecularmechanismsimmunopreventionandtherapeuticapproaches
AT abirmehedyhasan multidrugresistanceincancerunderstandingmolecularmechanismsimmunopreventionandtherapeuticapproaches
AT siddiqueemohdfaijanurrob multidrugresistanceincancerunderstandingmolecularmechanismsimmunopreventionandtherapeuticapproaches
AT ahmedhossain multidrugresistanceincancerunderstandingmolecularmechanismsimmunopreventionandtherapeuticapproaches
AT rahmannova multidrugresistanceincancerunderstandingmolecularmechanismsimmunopreventionandtherapeuticapproaches
AT nainufirzan multidrugresistanceincancerunderstandingmolecularmechanismsimmunopreventionandtherapeuticapproaches
AT wahyudinelly multidrugresistanceincancerunderstandingmolecularmechanismsimmunopreventionandtherapeuticapproaches
AT mitrasaikat multidrugresistanceincancerunderstandingmolecularmechanismsimmunopreventionandtherapeuticapproaches
AT dhamakuldeep multidrugresistanceincancerunderstandingmolecularmechanismsimmunopreventionandtherapeuticapproaches
AT habiballahmahmoudm multidrugresistanceincancerunderstandingmolecularmechanismsimmunopreventionandtherapeuticapproaches
AT haqueshafiul multidrugresistanceincancerunderstandingmolecularmechanismsimmunopreventionandtherapeuticapproaches
AT islamariful multidrugresistanceincancerunderstandingmolecularmechanismsimmunopreventionandtherapeuticapproaches
AT hassanmohammadmahmudul multidrugresistanceincancerunderstandingmolecularmechanismsimmunopreventionandtherapeuticapproaches