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Stromal CD10 expression in gastric adenocarcinoma
Gastric adenocarcinoma is a malignant neoplasm of the gastric mucosa composed of neoplastic cells and supporting stroma as with any neoplasm. Stromal myofibroblasts have an essential role in creating the tumor-promoting environment. They express certain substances, such as CD10. In this study, strom...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Carol Davila University Press
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262272/ https://www.ncbi.nlm.nih.gov/pubmed/35815076 http://dx.doi.org/10.25122/jml-2021-0244 |
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author | Aziz, Sara Jalal Jalal, Jalal Ali Hamadameen, Kalthuma Saleh |
author_facet | Aziz, Sara Jalal Jalal, Jalal Ali Hamadameen, Kalthuma Saleh |
author_sort | Aziz, Sara Jalal |
collection | PubMed |
description | Gastric adenocarcinoma is a malignant neoplasm of the gastric mucosa composed of neoplastic cells and supporting stroma as with any neoplasm. Stromal myofibroblasts have an essential role in creating the tumor-promoting environment. They express certain substances, such as CD10. In this study, stromal CD10 expression was investigated by immunohistochemistry in gastric carcinoma, and its association with specific clinicopathological parameters was analyzed. Formalin-fixed paraffin-embedded blocks of 80 gastric adenocarcinoma cases were collected retrospectively in a private laboratory of the Rizgary Teaching Hospital for 2 years (January 2018–January 2020). Finally, the immunohistochemical study of CD10 expression in stromal cells was performed. According to the results, stromal CD10 immunoreactivity was detected in 15% of the cases. Furthermore, a statistically significant correlation was observed between stromal CD10 and the tumor type (P=0.015). However, no statistically significant relationship was identified between stromal CD10 expression and patients' age, gender, lymphovascular invasion, lymph node status, and tumor stage and grade. The results suggest a statistically significant positive correlation between stromal CD10 expression and tumor type. |
format | Online Article Text |
id | pubmed-9262272 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Carol Davila University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-92622722022-07-08 Stromal CD10 expression in gastric adenocarcinoma Aziz, Sara Jalal Jalal, Jalal Ali Hamadameen, Kalthuma Saleh J Med Life Original Article Gastric adenocarcinoma is a malignant neoplasm of the gastric mucosa composed of neoplastic cells and supporting stroma as with any neoplasm. Stromal myofibroblasts have an essential role in creating the tumor-promoting environment. They express certain substances, such as CD10. In this study, stromal CD10 expression was investigated by immunohistochemistry in gastric carcinoma, and its association with specific clinicopathological parameters was analyzed. Formalin-fixed paraffin-embedded blocks of 80 gastric adenocarcinoma cases were collected retrospectively in a private laboratory of the Rizgary Teaching Hospital for 2 years (January 2018–January 2020). Finally, the immunohistochemical study of CD10 expression in stromal cells was performed. According to the results, stromal CD10 immunoreactivity was detected in 15% of the cases. Furthermore, a statistically significant correlation was observed between stromal CD10 and the tumor type (P=0.015). However, no statistically significant relationship was identified between stromal CD10 expression and patients' age, gender, lymphovascular invasion, lymph node status, and tumor stage and grade. The results suggest a statistically significant positive correlation between stromal CD10 expression and tumor type. Carol Davila University Press 2022-05 /pmc/articles/PMC9262272/ /pubmed/35815076 http://dx.doi.org/10.25122/jml-2021-0244 Text en © 2022 JOURNAL of MEDICINE and LIFE https://creativecommons.org/licenses/by/3.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Original Article Aziz, Sara Jalal Jalal, Jalal Ali Hamadameen, Kalthuma Saleh Stromal CD10 expression in gastric adenocarcinoma |
title | Stromal CD10 expression in gastric adenocarcinoma |
title_full | Stromal CD10 expression in gastric adenocarcinoma |
title_fullStr | Stromal CD10 expression in gastric adenocarcinoma |
title_full_unstemmed | Stromal CD10 expression in gastric adenocarcinoma |
title_short | Stromal CD10 expression in gastric adenocarcinoma |
title_sort | stromal cd10 expression in gastric adenocarcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262272/ https://www.ncbi.nlm.nih.gov/pubmed/35815076 http://dx.doi.org/10.25122/jml-2021-0244 |
work_keys_str_mv | AT azizsarajalal stromalcd10expressioningastricadenocarcinoma AT jalaljalalali stromalcd10expressioningastricadenocarcinoma AT hamadameenkalthumasaleh stromalcd10expressioningastricadenocarcinoma |