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Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT

Kanack and colleagues analyze anti-platelet factor 4 antibodies from 5 patients with vaccine-induced thrombotic thrombocytopenia (VITT) secondary to COVID-19 adenoviral vaccination and antibodies from patients with spontaneous heparin-induced thrombocytopenia (HIT) and classical HIT. VITT antibodies...

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Autores principales: Kanack, Adam J., Bayas, Antonios, George, Gemlyn, Abou-Ismail, Mouhamed Yazan, Singh, Bandana, Kohlhagen, Mindy C., Splinter, Noah P., Christ, Monika, Naumann, Markus, Moser, Karen A., Smock, Kristi J., Grazioli, Alison, Wen, Renren, Wang, Demin, Murray, David L., Padmanabhan, Anand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262283/
https://www.ncbi.nlm.nih.gov/pubmed/35560046
http://dx.doi.org/10.1182/blood.2021014588
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author Kanack, Adam J.
Bayas, Antonios
George, Gemlyn
Abou-Ismail, Mouhamed Yazan
Singh, Bandana
Kohlhagen, Mindy C.
Splinter, Noah P.
Christ, Monika
Naumann, Markus
Moser, Karen A.
Smock, Kristi J.
Grazioli, Alison
Wen, Renren
Wang, Demin
Murray, David L.
Padmanabhan, Anand
author_facet Kanack, Adam J.
Bayas, Antonios
George, Gemlyn
Abou-Ismail, Mouhamed Yazan
Singh, Bandana
Kohlhagen, Mindy C.
Splinter, Noah P.
Christ, Monika
Naumann, Markus
Moser, Karen A.
Smock, Kristi J.
Grazioli, Alison
Wen, Renren
Wang, Demin
Murray, David L.
Padmanabhan, Anand
author_sort Kanack, Adam J.
collection PubMed
description Kanack and colleagues analyze anti-platelet factor 4 antibodies from 5 patients with vaccine-induced thrombotic thrombocytopenia (VITT) secondary to COVID-19 adenoviral vaccination and antibodies from patients with spontaneous heparin-induced thrombocytopenia (HIT) and classical HIT. VITT antibodies are monoclonal or oligoclonal, similar to spontaneous HIT, whereas classical HIT antibodies are polyclonal. Heparin inhibits antibody-induced platelet activation in VITT, suggesting that heparin should be considered for the treatment of VITT.
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spelling pubmed-92622832022-07-08 Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT Kanack, Adam J. Bayas, Antonios George, Gemlyn Abou-Ismail, Mouhamed Yazan Singh, Bandana Kohlhagen, Mindy C. Splinter, Noah P. Christ, Monika Naumann, Markus Moser, Karen A. Smock, Kristi J. Grazioli, Alison Wen, Renren Wang, Demin Murray, David L. Padmanabhan, Anand Blood Letter to Blood Kanack and colleagues analyze anti-platelet factor 4 antibodies from 5 patients with vaccine-induced thrombotic thrombocytopenia (VITT) secondary to COVID-19 adenoviral vaccination and antibodies from patients with spontaneous heparin-induced thrombocytopenia (HIT) and classical HIT. VITT antibodies are monoclonal or oligoclonal, similar to spontaneous HIT, whereas classical HIT antibodies are polyclonal. Heparin inhibits antibody-induced platelet activation in VITT, suggesting that heparin should be considered for the treatment of VITT. American Society of Hematology 2022-07-07 /pmc/articles/PMC9262283/ /pubmed/35560046 http://dx.doi.org/10.1182/blood.2021014588 Text en © 2022 by The American Society of Hematology
spellingShingle Letter to Blood
Kanack, Adam J.
Bayas, Antonios
George, Gemlyn
Abou-Ismail, Mouhamed Yazan
Singh, Bandana
Kohlhagen, Mindy C.
Splinter, Noah P.
Christ, Monika
Naumann, Markus
Moser, Karen A.
Smock, Kristi J.
Grazioli, Alison
Wen, Renren
Wang, Demin
Murray, David L.
Padmanabhan, Anand
Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT
title Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT
title_full Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT
title_fullStr Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT
title_full_unstemmed Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT
title_short Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT
title_sort monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate vitt
topic Letter to Blood
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262283/
https://www.ncbi.nlm.nih.gov/pubmed/35560046
http://dx.doi.org/10.1182/blood.2021014588
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