Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice

Caloric restriction (CR) prolongs lifespan, yet the mechanisms by which it does so remain poorly understood. Under CR, mice self-impose chronic cycles of 2-hour-feeding and 22-hour-fasting, raising the question whether calories, fasting, or time of day are causal. We show that 30%-CR is sufficient t...

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Detalles Bibliográficos
Autores principales: Acosta-Rodríguez, Victoria, Rijo-Ferreira, Filipa, Izumo, Mariko, Xu, Pin, Wight-Carter, Mary, Green, Carla B., Takahashi, Joseph S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262309/
https://www.ncbi.nlm.nih.gov/pubmed/35511946
http://dx.doi.org/10.1126/science.abk0297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262309/
https://www.ncbi.nlm.nih.gov/pubmed/35511946
http://dx.doi.org/10.1126/science.abk0297

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