Pirfenidone ameliorates pulmonary arterial pressure and neointimal remodeling in experimental pulmonary arterial hypertension by suppressing NLRP3 inflammasome activation

Pulmonary arterial hypertension (PAH) is a fatal disease characterized by increased pulmonary arterial pressure, inflammation, and neointimal remodeling of pulmonary arterioles. Serum levels of interleukin (IL)‐1β and IL‐18 are elevated in PAH patients and may enhance proinflammatory neointimal remo...

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Detalles Bibliográficos
Autores principales: Mavrogiannis, Emmanouil, Hagdorn, Quint A. J., Bazioti, Venetia, Douwes, Johannes M., Van Der Feen, Diederik E., Oberdorf‐Maass, Silke U., Westerterp, Marit, Berger, Rolf M. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262321/
https://www.ncbi.nlm.nih.gov/pubmed/35833096
http://dx.doi.org/10.1002/pul2.12101

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