Case Report: An Adolescent Soft Tissue Sarcoma With YWHAE-NUTM2B Fusion Is Effectively Treated With Combined Therapy of Epirubicin and Anlotinib

Soft tissue sarcoma is a relatively rare entity that comprises heterogeneous types of tumors. Here we report the case of a 14-year-old girl with pelvic sarcoma with a YWHAE-NUTM2B fusion gene. This fusion transcript has been reported in endometrial stromal sarcomas and clear cell renal sarcomas, but...

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Autores principales: He, Jiajia, Xu, Yanjie, Ni, Xuefeng, Zhang, Dachuan, Zhao, Jiemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262382/
https://www.ncbi.nlm.nih.gov/pubmed/35814390
http://dx.doi.org/10.3389/fonc.2022.905994
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author He, Jiajia
Xu, Yanjie
Ni, Xuefeng
Zhang, Dachuan
Zhao, Jiemin
author_facet He, Jiajia
Xu, Yanjie
Ni, Xuefeng
Zhang, Dachuan
Zhao, Jiemin
author_sort He, Jiajia
collection PubMed
description Soft tissue sarcoma is a relatively rare entity that comprises heterogeneous types of tumors. Here we report the case of a 14-year-old girl with pelvic sarcoma with a YWHAE-NUTM2B fusion gene. This fusion transcript has been reported in endometrial stromal sarcomas and clear cell renal sarcomas, but its description in pelvic sarcomas is recent. To our knowledge, this is the first case report describing this translocation in an adolescent patient with soft tissue sarcoma. The patient underwent cytoreductive surgery, followed by systemic chemotherapy and targeted drug treatment. Surprisingly, the treatment was effective, and the young patient is being followed up in our department.
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spelling pubmed-92623822022-07-08 Case Report: An Adolescent Soft Tissue Sarcoma With YWHAE-NUTM2B Fusion Is Effectively Treated With Combined Therapy of Epirubicin and Anlotinib He, Jiajia Xu, Yanjie Ni, Xuefeng Zhang, Dachuan Zhao, Jiemin Front Oncol Oncology Soft tissue sarcoma is a relatively rare entity that comprises heterogeneous types of tumors. Here we report the case of a 14-year-old girl with pelvic sarcoma with a YWHAE-NUTM2B fusion gene. This fusion transcript has been reported in endometrial stromal sarcomas and clear cell renal sarcomas, but its description in pelvic sarcomas is recent. To our knowledge, this is the first case report describing this translocation in an adolescent patient with soft tissue sarcoma. The patient underwent cytoreductive surgery, followed by systemic chemotherapy and targeted drug treatment. Surprisingly, the treatment was effective, and the young patient is being followed up in our department. Frontiers Media S.A. 2022-06-23 /pmc/articles/PMC9262382/ /pubmed/35814390 http://dx.doi.org/10.3389/fonc.2022.905994 Text en Copyright © 2022 He, Xu, Ni, Zhang and Zhao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
He, Jiajia
Xu, Yanjie
Ni, Xuefeng
Zhang, Dachuan
Zhao, Jiemin
Case Report: An Adolescent Soft Tissue Sarcoma With YWHAE-NUTM2B Fusion Is Effectively Treated With Combined Therapy of Epirubicin and Anlotinib
title Case Report: An Adolescent Soft Tissue Sarcoma With YWHAE-NUTM2B Fusion Is Effectively Treated With Combined Therapy of Epirubicin and Anlotinib
title_full Case Report: An Adolescent Soft Tissue Sarcoma With YWHAE-NUTM2B Fusion Is Effectively Treated With Combined Therapy of Epirubicin and Anlotinib
title_fullStr Case Report: An Adolescent Soft Tissue Sarcoma With YWHAE-NUTM2B Fusion Is Effectively Treated With Combined Therapy of Epirubicin and Anlotinib
title_full_unstemmed Case Report: An Adolescent Soft Tissue Sarcoma With YWHAE-NUTM2B Fusion Is Effectively Treated With Combined Therapy of Epirubicin and Anlotinib
title_short Case Report: An Adolescent Soft Tissue Sarcoma With YWHAE-NUTM2B Fusion Is Effectively Treated With Combined Therapy of Epirubicin and Anlotinib
title_sort case report: an adolescent soft tissue sarcoma with ywhae-nutm2b fusion is effectively treated with combined therapy of epirubicin and anlotinib
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262382/
https://www.ncbi.nlm.nih.gov/pubmed/35814390
http://dx.doi.org/10.3389/fonc.2022.905994
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