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NSD1 mutations deregulate transcription and DNA methylation of bivalent developmental genes in Sotos syndrome

Sotos syndrome (SS), the most common overgrowth with intellectual disability (OGID) disorder, is caused by inactivating germline mutations of NSD1, which encodes a histone H3 lysine 36 methyltransferase. To understand how NSD1 inactivation deregulates transcription and DNA methylation (DNAm), and to...

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Detalles Bibliográficos
Autores principales:	Brennan, Kevin, Zheng, Hong, Fahrner, Jill A, Shin, June Ho, Gentles, Andrew J, Schaefer, Bradley, Sunwoo, John B, Bernstein, Jonathan A, Gevaert, Olivier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262396/ https://www.ncbi.nlm.nih.gov/pubmed/35094088 http://dx.doi.org/10.1093/hmg/ddac026

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