Cargando…

Host cell RecA activates a mobile element-encoded mutagenic DNA polymerase

Homologs of the mutagenic Escherichia coli DNA polymerase V (pol V) are encoded by numerous pathogens and mobile elements. We have used Rum pol (RumA′(2)B), from the integrative conjugative element (ICE), R391, as a model mobile element-encoded polymerase (MEPol). The highly mutagenic Rum pol is tra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ojha, Debika, Jaszczur, Malgorzata M, Sikand, Adhirath, McDonald, John P, Robinson, Andrew, van Oijen, Antoine M, Mak, Chi H, Pinaud, Fabien, Cox, Michael M, Woodgate, Roger, Goodman, Myron F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262582/ https://www.ncbi.nlm.nih.gov/pubmed/35736210 http://dx.doi.org/10.1093/nar/gkac515

Ejemplares similares

Conformational regulation of Escherichia coli DNA polymerase V by RecA and ATP
por: Jaszczur, Malgorzata M., et al.
Publicado: (2019)

RecA and SSB genome-wide distribution in ssDNA gaps and ends in Escherichia coli
por: Pham, Phuong, et al.
Publicado: (2023)

A dual role for mycobacterial RecO in RecA-dependent homologous recombination and RecA-independent single-strand annealing
por: Gupta, Richa, et al.
Publicado: (2013)

The RecD2 helicase balances RecA activities
por: Ramos, Cristina, et al.
Publicado: (2022)

PcrA-mediated disruption of RecA nucleoprotein filaments—essential role of the ATPase activity of RecA
por: Fagerburg, Matt V., et al.
Publicado: (2012)

Polynucleotide phosphorylase exonuclease and polymerase activities on single-stranded DNA ends are modulated by RecN, SsbA and RecA proteins
por: Cardenas, Paula P., et al.
Publicado: (2011)

Single-molecule live-cell imaging reveals RecB-dependent function of DNA polymerase IV in double strand break repair
por: Henrikus, Sarah S, et al.
Publicado: (2020)

Dynamics of RecA filaments on single-stranded DNA
por: van Loenhout, Marijn T. J., et al.
Publicado: (2009)

Bacillus subtilis RecA and its accessory factors, RecF, RecO, RecR and RecX, are required for spore resistance to DNA double-strand break
por: Vlašić, Ignacija, et al.
Publicado: (2014)

Molecular mechanism of sequence-dependent stability of RecA filament
por: Kim, Sung Hyun, et al.
Publicado: (2013)

Cooperative RecA clustering: the key to efficient homology searching
por: Lee, Andrew J., et al.
Publicado: (2017)

Bacillus subtilis RecO and SsbA are crucial for RecA-mediated recombinational DNA repair
por: Carrasco, Begoña, et al.
Publicado: (2015)

Mechanical force antagonizes the inhibitory effects of RecX on RecA filament formation in Mycobacterium tuberculosis
por: Le, Shimin, et al.
Publicado: (2014)

Use of RecA fusion proteins to induce genomic modifications in zebrafish
por: Liao, Hsin-Kai, et al.
Publicado: (2011)

Bacillus subtilis RecA with DprA–SsbA antagonizes RecX function during natural transformation
por: Le, Shimin, et al.
Publicado: (2017)

RecA stimulates AlkB-mediated direct repair of DNA adducts
por: Shivange, Gururaj, et al.
Publicado: (2016)

Bacillus subtilis DisA regulates RecA-mediated DNA strand exchange
por: Torres, Rubén, et al.
Publicado: (2019)

Micro-homology intermediates: RecA’s transient sampling revealed at the single molecule level
por: Lee, Andrew J, et al.
Publicado: (2021)

Flanking strand separation activity of RecA nucleoprotein filaments in DNA strand exchange reactions
por: Yu, Fangzhi, et al.
Publicado: (2023)

RecFOR epistasis group: RecF and RecO have distinct localizations and functions in Escherichia coli
por: Henrikus, Sarah S, et al.
Publicado: (2019)

A 5′-to-3′ strand exchange polarity is intrinsic to RecA nucleoprotein filaments in the absence of ATP hydrolysis
por: Lin, Yu-Hsuan, et al.
Publicado: (2019)

Force and ATP hydrolysis dependent regulation of RecA nucleoprotein filament by single-stranded DNA binding protein
por: Fu, Hongxia, et al.
Publicado: (2013)

Complex activities of the human Bloom's syndrome helicase are encoded in a core region comprising the RecA and Zn-binding domains
por: Gyimesi, Máté, et al.
Publicado: (2012)

A RecA Protein Surface Required for Activation of DNA Polymerase V
por: Gruber, Angela J., et al.
Publicado: (2015)

Loop L1 governs the DNA-binding specificity and order for RecA-catalyzed reactions in homologous recombination and DNA repair
por: Shinohara, Takeshi, et al.
Publicado: (2015)

Bacillus subtilis RecA interacts with and loads RadA/Sms to unwind recombination intermediates during natural chromosomal transformation
por: Torres, Rubén, et al.
Publicado: (2019)

The ATPase activity of E. coli RecA prevents accumulation of toxic complexes formed by erroneous binding to undamaged double stranded DNA
por: Gataulin, Daniil V, et al.
Publicado: (2018)

E. coli Rep helicase and RecA recombinase unwind G4 DNA and are important for resistance to G4-stabilizing ligands
por: Paul, Tapas, et al.
Publicado: (2020)

Integrating multi-scale data on homologous recombination into a new recognition mechanism based on simulations of the RecA-ssDNA/dsDNA structure
por: Yang, Darren, et al.
Publicado: (2015)

Mutagenic mechanisms of cancer-associated DNA polymerase ϵ alleles
por: Herzog, Mareike, et al.
Publicado: (2021)

The SOS Error-Prone DNA Polymerase V Mutasome and β-Sliding Clamp Acting in Concert on Undamaged DNA and during Translesion Synthesis
por: Sikand, Adhirath, et al.
Publicado: (2021)

Mycobacterium tuberculosis nucleoid-associated DNA-binding protein H-NS binds with high-affinity to the Holliday junction and inhibits strand exchange promoted by RecA protein
por: Sharadamma, N., et al.
Publicado: (2010)

RNase H1C collaborates with ssDNA binding proteins WHY1/3 and recombinase RecA1 to fulfill the DNA damage repair in Arabidopsis chloroplasts
por: Wang, Wenjie, et al.
Publicado: (2021)

DNA polymerases κ and ζ cooperatively perform mutagenic translesion synthesis of the C8–2′-deoxyguanosine adduct of the dietary mutagen IQ in human cells
por: Bose, Arindam, et al.
Publicado: (2015)

Human DNA polymerase α has a strong mutagenic potential at the initial steps of DNA synthesis
por: Lisova, Alisa E, et al.
Publicado: (2022)

Resolving Toxic DNA repair intermediates in every E. coli replication cycle: critical roles for RecG, Uup and RadD
por: Romero, Zachary J, et al.
Publicado: (2020)

Allosteric effects of E. coli SSB and RecR proteins on RecO protein binding to DNA
por: Shinn, Min Kyung, et al.
Publicado: (2023)

The RecB helicase-nuclease tether mediates Chi hotspot control of RecBCD enzyme
por: Amundsen, Susan K, et al.
Publicado: (2019)

DNA polymerase η contributes to genome-wide lagging strand synthesis
por: Kreisel, Katrin, et al.
Publicado: (2019)

Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations
por: Kochenova, Olga V., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_e082i3armvisq2gmqp3ulrm06s