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Migrating bubble synthesis promotes mutagenesis through lesions in its template

Break-induced replication (BIR) proceeds via a migrating D-loop for hundreds of kilobases and is highly mutagenic. Previous studies identified long single-stranded (ss) nascent DNA that accumulates during leading strand synthesis to be a target for DNA damage and a primary source of BIR-induced muta...

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Detalles Bibliográficos
Autores principales:	Osia, Beth, Twarowski, Jerzy, Jackson, Tyler, Lobachev, Kirill, Liu, Liping, Malkova, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262586/ https://www.ncbi.nlm.nih.gov/pubmed/35748867 http://dx.doi.org/10.1093/nar/gkac520

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