U-shaped association between abnormal serum uric acid levels and COVID-19 severity: reports from the Japan COVID-19 Task Force

OBJECTIVES: This study aimed to identify the relationship between abnormal serum uric acid levels or a history of hyperuricemia and COVID-19 severity in the Japanese population. METHODS: We included 1523 patients enrolled in the Japan COVID-19 Task Force cohort between February 2020 and May 2021. We...

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Detalles Bibliográficos
Autores principales: Fukushima, Takahiro, Chubachi, Shotaro, Namkoong, Ho, Otake, Shiro, Nakagawara, Kensuke, Tanaka, Hiromu, Lee, Ho, Morita, Atsuho, Watase, Mayuko, Kusumoto, Tatsuya, Masaki, Katsunori, Kamata, Hirofumi, Ishii, Makoto, Hasegawa, Naoki, Harada, Norihiro, Ueda, Tetsuya, Ueda, Soichiro, Ishiguro, Takashi, Arimura, Ken, Saito, Fukuki, Yoshiyama, Takashi, Nakano, Yasushi, Mutoh, Yoshikazu, Suzuki, Yusuke, Murakami, Koji, Okada, Yukinori, Koike, Ryuji, Kitagawa, Yuko, Kimura, Akinori, Imoto, Seiya, Miyano, Satoru, Ogawa, Seishi, Kanai, Takanori, Fukunaga, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262647/
https://www.ncbi.nlm.nih.gov/pubmed/35811077
http://dx.doi.org/10.1016/j.ijid.2022.07.014
Descripción
Sumario:OBJECTIVES: This study aimed to identify the relationship between abnormal serum uric acid levels or a history of hyperuricemia and COVID-19 severity in the Japanese population. METHODS: We included 1523 patients enrolled in the Japan COVID-19 Task Force cohort between February 2020 and May 2021. We compared the clinical characteristics, including co-morbidities, laboratory findings, and outcomes, particularly invasive mechanical ventilation (IMV), among patients with and without abnormal uric acid levels or a history of hyperuricemia. RESULTS: Patients with high serum uric acid levels were older and had higher body weight and body mass index than those without. In addition, the multiple logistic regression analysis revealed a significant association between high serum uric acid levels or a history of hyperuricemia and an increased risk of IMV (odds ratio [OR] = 1.77; P = 0.03/OR = 1.56; P = 0.04). Moreover, patients with low uric acid levels on admission were also associated significantly with the requirement of IMV (OR = 5.09; P <0.0001). CONCLUSION: Abnormal serum uric acid levels or a history of hyperuricemia were significantly associated with COVID-19 severity in the Japanese cohort.

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