Humoral and cellular immune response levels at a 1-year follow-up after mild COVID-19

The primary objective of this study was to establish a 1-year follow-up of patients after mild COVID-19 with no or only short-term detection of antibodies shortly after disease. At 1 year after disease, cellular memory against SARS-CoV-2, as measured by IFN-γ release by T cells, was detected in 76%...

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Autores principales: Flieder, Tobias, Fischer, Bastian, von Bargen, Katharina, Peter, Andreas, Knabbe, Cornelius, Birschmann, Ingvild
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Guidelines
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262650/
https://www.ncbi.nlm.nih.gov/pubmed/35896052
http://dx.doi.org/10.1016/j.jcv.2022.105236
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author Flieder, Tobias
Fischer, Bastian
von Bargen, Katharina
Peter, Andreas
Knabbe, Cornelius
Birschmann, Ingvild
author_facet Flieder, Tobias
Fischer, Bastian
von Bargen, Katharina
Peter, Andreas
Knabbe, Cornelius
Birschmann, Ingvild
author_sort Flieder, Tobias
collection PubMed
description The primary objective of this study was to establish a 1-year follow-up of patients after mild COVID-19 with no or only short-term detection of antibodies shortly after disease. At 1 year after disease, cellular memory against SARS-CoV-2, as measured by IFN-γ release by T cells, was detected in 76% (38/50) of participants. The data suggest that even if antibody levels decline after the primary infection has resolved, a cellular immune response may be detectable for longer.
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spelling pubmed-92626502022-07-08 Humoral and cellular immune response levels at a 1-year follow-up after mild COVID-19 Flieder, Tobias Fischer, Bastian von Bargen, Katharina Peter, Andreas Knabbe, Cornelius Birschmann, Ingvild J Clin Virol Guidelines The primary objective of this study was to establish a 1-year follow-up of patients after mild COVID-19 with no or only short-term detection of antibodies shortly after disease. At 1 year after disease, cellular memory against SARS-CoV-2, as measured by IFN-γ release by T cells, was detected in 76% (38/50) of participants. The data suggest that even if antibody levels decline after the primary infection has resolved, a cellular immune response may be detectable for longer. Elsevier B.V. 2022-09 2022-07-08 /pmc/articles/PMC9262650/ /pubmed/35896052 http://dx.doi.org/10.1016/j.jcv.2022.105236 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Guidelines
Flieder, Tobias
Fischer, Bastian
von Bargen, Katharina
Peter, Andreas
Knabbe, Cornelius
Birschmann, Ingvild
Humoral and cellular immune response levels at a 1-year follow-up after mild COVID-19
title Humoral and cellular immune response levels at a 1-year follow-up after mild COVID-19
title_full Humoral and cellular immune response levels at a 1-year follow-up after mild COVID-19
title_fullStr Humoral and cellular immune response levels at a 1-year follow-up after mild COVID-19
title_full_unstemmed Humoral and cellular immune response levels at a 1-year follow-up after mild COVID-19
title_short Humoral and cellular immune response levels at a 1-year follow-up after mild COVID-19
title_sort humoral and cellular immune response levels at a 1-year follow-up after mild covid-19
topic Guidelines
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262650/
https://www.ncbi.nlm.nih.gov/pubmed/35896052
http://dx.doi.org/10.1016/j.jcv.2022.105236
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