Cargando…

Short-Chain Fatty Acids Attenuate Renal Fibrosis and Enhance Autophagy of Renal Tubular Cells in Diabetic Mice Through the HDAC2/ULK1 Axis

BACKGROUND: This study investigated the effect of short-chain fatty acids (SCFAs) on diabetes in a mouse model. METHODS: Autophagy in Akita mice and streptozocin (STZ)-induced diabetic C57BL/6 mice was determined by Western blots and immunohistochemistry (IHC). Western blots, IHC, hematoxylin and eo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Xiaoying, Wang, Qiong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Endocrine Society 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262686/ https://www.ncbi.nlm.nih.gov/pubmed/35574586 http://dx.doi.org/10.3803/EnM.2021.1336

Ejemplares similares

Tubular Overexpression of Angiopoietin-1 Attenuates Renal Fibrosis
por: Singh, Sudhir, et al.
Publicado: (2016)

Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis
por: Gong, Wangqiu, et al.
Publicado: (2021)

Reciprocal regulation between ER stress and autophagy in renal tubular fibrosis and apoptosis
por: Shu, Shaoqun, et al.
Publicado: (2021)

Proximal tubular RAGE mediated the renal fibrosis in UUO model mice via upregulation of autophagy
por: Liu, Bohao, et al.
Publicado: (2022)

MYCT1 attenuates renal fibrosis and tubular injury in diabetic kidney disease
por: Li, Xin, et al.
Publicado: (2023)

Hyperoside attenuates renal aging and injury induced by D-galactose via inhibiting AMPK-ULK1 signaling-mediated autophagy
por: Liu, Buhui, et al.
Publicado: (2018)

Cellular senescence of renal tubular epithelial cells in renal fibrosis
por: Zhang, Jun-Qing, et al.
Publicado: (2023)

Autophagy in inflammation: the p38α MAPK-ULK1 axis
por: She, Hua, et al.
Publicado: (2018)

Omega-3 Fatty Acids Attenuate Renal Fibrosis via AMPK-Mediated Autophagy Flux Activation
por: Han, Suyeon, et al.
Publicado: (2023)

Liproxstatin-1 attenuates unilateral ureteral obstruction-induced renal fibrosis by inhibiting renal tubular epithelial cells ferroptosis
por: Zhang, Bo, et al.
Publicado: (2021)

Autophagy and Renal Fibrosis
por: Liang, Shan, et al.
Publicado: (2022)

Metformin attenuates diabetic renal injury via the AMPK-autophagy axis
por: Sun, Tingli, et al.
Publicado: (2021)

4336 Renal Tubular Complement C9 Deposition is Associated with Renal Tubular Damage and Fibrosis in Lupus Nephritis
por: Wang, Shudan, et al.
Publicado: (2020)

Emerging roles of proximal tubular endocytosis in renal fibrosis
por: Chen, Min, et al.
Publicado: (2023)

Positive correlation between renal tubular flattening and renal tubular injury/interstitial fibrosis in murine kidney disease models
por: TAKAHASHI, Yuki, et al.
Publicado: (2021)

Pharmacological and Genetic Inhibition of HDAC4 Alleviates Renal Injury and Fibrosis in Mice
por: Shen, Fengchen, et al.
Publicado: (2022)

Nicotinamide Mononucleotide Attenuates Renal Interstitial Fibrosis After AKI by Suppressing Tubular DNA Damage and Senescence
por: Jia, Yan, et al.
Publicado: (2021)

Plk1 promotes renal tubulointerstitial fibrosis by targeting autophagy/lysosome axis
por: Du, Yang, et al.
Publicado: (2023)

STAT6 contributes to renal fibrosis by modulating PPARα-mediated tubular fatty acid oxidation
por: Li, Jianzhong, et al.
Publicado: (2022)

HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury
por: Aufhauser, David D., et al.
Publicado: (2021)

Fluorofenidone inhibits apoptosis of renal tubular epithelial cells in rats with renal interstitial fibrosis
por: Yang, Hui, et al.
Publicado: (2019)

Inhibition of autophagy-attenuated calcium oxalate crystal-induced renal tubular epithelial cell injury in vivo and in vitro
por: Liu, Yunlong, et al.
Publicado: (2017)

Tubular HIPK2 is a key contributor to renal fibrosis
por: Xiao, Wenzhen, et al.
Publicado: (2020)

Irbesartan Ameliorates Lipid Deposition by Enhancing Autophagy via PKC/AMPK/ULK1 Axis in Free Fatty Acid Induced Hepatocytes
por: He, Juan, et al.
Publicado: (2019)

Autophagy activation reduces renal tubular injury induced by urinary proteins
por: Liu, Wei Jing, et al.
Publicado: (2014)

Depleted HDAC3 attenuates hyperuricemia-induced renal interstitial fibrosis via miR-19b-3p/SF3B3 axis
por: Hu, Langtao, et al.
Publicado: (2022)

Autophagy in renal fibrosis: Protection or promotion?
por: Dai, Rong, et al.
Publicado: (2022)

Autophagy inhibition attenuates hyperoxaluria-induced renal tubular oxidative injury and calcium oxalate crystal depositions in the rat kidney
por: Duan, Xiaolu, et al.
Publicado: (2018)

The Association of AMPK with ULK1 Regulates Autophagy
por: Lee, Jong Woo, et al.
Publicado: (2010)

The mammalian ULK1 complex and autophagy initiation
por: Zachari, Maria, et al.
Publicado: (2017)

Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation
por: Zheng, Meiling, et al.
Publicado: (2019)

BMPER Ameliorates Renal Fibrosis by Inhibiting Tubular Dedifferentiation and Fibroblast Activation
por: Xie, Ting, et al.
Publicado: (2021)

Bilirubin attenuates the renal tubular injury by inhibition of oxidative stress and apoptosis
por: Oh, Se Won, et al.
Publicado: (2013)

A new LKB1 activator, piericidin analogue S14, retards renal fibrosis through promoting autophagy and mitochondrial homeostasis in renal tubular epithelial cells
por: Liu, Canzhen, et al.
Publicado: (2022)

Roles for VEGF‐C/NRP–2 axis in regulating renal tubular epithelial cell survival and autophagy during serum deprivation
por: Chang, Xiaoyan, et al.
Publicado: (2019)

Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells
por: Miao, Jinhua, et al.
Publicado: (2021)

Perinatal versus adult loss of ULK1 and ULK2 distinctly influences cardiac autophagy and function
por: Harris, Matthew P., et al.
Publicado: (2022)

Advanced oxidation protein products inhibit the autophagy of renal tubular epithelial cells
por: Zhang, Jun, et al.
Publicado: (2018)

The Urinary Microbiome; Axis Crosstalk and Short-Chain Fatty Acid
por: Yang, Hee Jo, et al.
Publicado: (2022)

Sinomenine Hydrochloride Attenuates Renal Fibrosis by Inhibiting Excessive Autophagy Induced by Adriamycin: An Experimental Study
por: Zhao, Ming-ming, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_l2b3r7ur7euu325gtqb2u3o52o