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Ampicillin Dosing in Premature Infants for Early-onset Sepsis: Exposure-driven Efficacy, Safety, and Stewardship

OBJECTIVE: Define optimal ampicillin dosing for empiric early-onset sepsis (EOS) therapy in preterm neonates. STUDY DESIGN: We simulated ampicillin concentrations in newborns (birthweight<1500g; gestational age 22–27 weeks), summarizing three 48-hour regimens: high 100mg/kg Q8hr, medium 100mg/kg...

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Detalles Bibliográficos
Autores principales:	Le, Jennifer, Greenberg, Rachel G., Yoo, YoungJun, Clark, Reese H., Benjamin, Daniel K., Zimmerman, Kanecia O., Cohen-Wolkowiez, Michael, Wade, Kelly C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262754/ https://www.ncbi.nlm.nih.gov/pubmed/35210541 http://dx.doi.org/10.1038/s41372-022-01344-2

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