Modulating mitofusins to control mitochondrial function and signaling

Mitofusins reside on the outer mitochondrial membrane and regulate mitochondrial fusion, a physiological process that impacts diverse cellular processes. Mitofusins are activated by conformational changes and subsequently oligomerize to enable mitochondrial fusion. Here, we identify small molecules...

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Detalles Bibliográficos
Autores principales: Zacharioudakis, Emmanouil, Agianian, Bogos, Kumar MV, Vasantha, Biris, Nikolaos, Garner, Thomas P., Rabinovich-Nikitin, Inna, Ouchida, Amanda T., Margulets, Victoria, Nordstrøm, Lars Ulrik, Riley, Joel S., Dolgalev, Igor, Chen, Yun, Wittig, Andre J. H., Pekson, Ryan, Mathew, Chris, Wei, Peter, Tsirigos, Aristotelis, Tait, Stephen W. G., Kirshenbaum, Lorrie A., Kitsis, Richard N., Gavathiotis, Evripidis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262907/
https://www.ncbi.nlm.nih.gov/pubmed/35798717
http://dx.doi.org/10.1038/s41467-022-31324-1

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