Cargando…

Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease

Although several studies have identified a distinct gut microbial composition in Parkinson’s disease (PD), few studies have investigated the oral microbiome or functional alteration of the microbiome in PD. We aimed to investigate the connection between the oral and gut microbiome and the functional...

Descripción completa

Detalles Bibliográficos
Autores principales: Jo, Sungyang, Kang, Woorim, Hwang, Yun Su, Lee, Seung Hyun, Park, Kye Won, Kim, Mi Sun, Lee, Hyunna, Yoon, Hyung Jeong, Park, Yoo Kyoung, Chalita, Mauricio, Lee, Je Hee, Sung, Hojun, Lee, Jae-Yun, Bae, Jin-Woo, Chung, Sun Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262988/
https://www.ncbi.nlm.nih.gov/pubmed/35798742
http://dx.doi.org/10.1038/s41531-022-00351-6
_version_ 1784742627569041408
author Jo, Sungyang
Kang, Woorim
Hwang, Yun Su
Lee, Seung Hyun
Park, Kye Won
Kim, Mi Sun
Lee, Hyunna
Yoon, Hyung Jeong
Park, Yoo Kyoung
Chalita, Mauricio
Lee, Je Hee
Sung, Hojun
Lee, Jae-Yun
Bae, Jin-Woo
Chung, Sun Ju
author_facet Jo, Sungyang
Kang, Woorim
Hwang, Yun Su
Lee, Seung Hyun
Park, Kye Won
Kim, Mi Sun
Lee, Hyunna
Yoon, Hyung Jeong
Park, Yoo Kyoung
Chalita, Mauricio
Lee, Je Hee
Sung, Hojun
Lee, Jae-Yun
Bae, Jin-Woo
Chung, Sun Ju
author_sort Jo, Sungyang
collection PubMed
description Although several studies have identified a distinct gut microbial composition in Parkinson’s disease (PD), few studies have investigated the oral microbiome or functional alteration of the microbiome in PD. We aimed to investigate the connection between the oral and gut microbiome and the functional changes in the PD-specific gut microbiome using shotgun metagenomic sequencing. The taxonomic composition of the oral and gut microbiome was significantly different between PD patients and healthy controls (P = 0.003 and 0.001, respectively). Oral Lactobacillus was more abundant in PD patients and was associated with opportunistic pathogens in the gut (FDR-adjusted P < 0.038). Functional analysis revealed that microbial gene markers for glutamate and arginine biosynthesis were downregulated, while antimicrobial resistance gene markers were upregulated in PD patients than healthy controls (all P < 0.001). We identified a connection between the oral and gut microbiota in PD, which might lead to functional alteration of the microbiome in PD.
format Online
Article
Text
id pubmed-9262988
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-92629882022-07-09 Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease Jo, Sungyang Kang, Woorim Hwang, Yun Su Lee, Seung Hyun Park, Kye Won Kim, Mi Sun Lee, Hyunna Yoon, Hyung Jeong Park, Yoo Kyoung Chalita, Mauricio Lee, Je Hee Sung, Hojun Lee, Jae-Yun Bae, Jin-Woo Chung, Sun Ju NPJ Parkinsons Dis Article Although several studies have identified a distinct gut microbial composition in Parkinson’s disease (PD), few studies have investigated the oral microbiome or functional alteration of the microbiome in PD. We aimed to investigate the connection between the oral and gut microbiome and the functional changes in the PD-specific gut microbiome using shotgun metagenomic sequencing. The taxonomic composition of the oral and gut microbiome was significantly different between PD patients and healthy controls (P = 0.003 and 0.001, respectively). Oral Lactobacillus was more abundant in PD patients and was associated with opportunistic pathogens in the gut (FDR-adjusted P < 0.038). Functional analysis revealed that microbial gene markers for glutamate and arginine biosynthesis were downregulated, while antimicrobial resistance gene markers were upregulated in PD patients than healthy controls (all P < 0.001). We identified a connection between the oral and gut microbiota in PD, which might lead to functional alteration of the microbiome in PD. Nature Publishing Group UK 2022-07-07 /pmc/articles/PMC9262988/ /pubmed/35798742 http://dx.doi.org/10.1038/s41531-022-00351-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Jo, Sungyang
Kang, Woorim
Hwang, Yun Su
Lee, Seung Hyun
Park, Kye Won
Kim, Mi Sun
Lee, Hyunna
Yoon, Hyung Jeong
Park, Yoo Kyoung
Chalita, Mauricio
Lee, Je Hee
Sung, Hojun
Lee, Jae-Yun
Bae, Jin-Woo
Chung, Sun Ju
Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease
title Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease
title_full Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease
title_fullStr Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease
title_full_unstemmed Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease
title_short Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease
title_sort oral and gut dysbiosis leads to functional alterations in parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262988/
https://www.ncbi.nlm.nih.gov/pubmed/35798742
http://dx.doi.org/10.1038/s41531-022-00351-6
work_keys_str_mv AT josungyang oralandgutdysbiosisleadstofunctionalalterationsinparkinsonsdisease
AT kangwoorim oralandgutdysbiosisleadstofunctionalalterationsinparkinsonsdisease
AT hwangyunsu oralandgutdysbiosisleadstofunctionalalterationsinparkinsonsdisease
AT leeseunghyun oralandgutdysbiosisleadstofunctionalalterationsinparkinsonsdisease
AT parkkyewon oralandgutdysbiosisleadstofunctionalalterationsinparkinsonsdisease
AT kimmisun oralandgutdysbiosisleadstofunctionalalterationsinparkinsonsdisease
AT leehyunna oralandgutdysbiosisleadstofunctionalalterationsinparkinsonsdisease
AT yoonhyungjeong oralandgutdysbiosisleadstofunctionalalterationsinparkinsonsdisease
AT parkyookyoung oralandgutdysbiosisleadstofunctionalalterationsinparkinsonsdisease
AT chalitamauricio oralandgutdysbiosisleadstofunctionalalterationsinparkinsonsdisease
AT leejehee oralandgutdysbiosisleadstofunctionalalterationsinparkinsonsdisease
AT sunghojun oralandgutdysbiosisleadstofunctionalalterationsinparkinsonsdisease
AT leejaeyun oralandgutdysbiosisleadstofunctionalalterationsinparkinsonsdisease
AT baejinwoo oralandgutdysbiosisleadstofunctionalalterationsinparkinsonsdisease
AT chungsunju oralandgutdysbiosisleadstofunctionalalterationsinparkinsonsdisease