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Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease
Although several studies have identified a distinct gut microbial composition in Parkinson’s disease (PD), few studies have investigated the oral microbiome or functional alteration of the microbiome in PD. We aimed to investigate the connection between the oral and gut microbiome and the functional...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262988/ https://www.ncbi.nlm.nih.gov/pubmed/35798742 http://dx.doi.org/10.1038/s41531-022-00351-6 |
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author | Jo, Sungyang Kang, Woorim Hwang, Yun Su Lee, Seung Hyun Park, Kye Won Kim, Mi Sun Lee, Hyunna Yoon, Hyung Jeong Park, Yoo Kyoung Chalita, Mauricio Lee, Je Hee Sung, Hojun Lee, Jae-Yun Bae, Jin-Woo Chung, Sun Ju |
author_facet | Jo, Sungyang Kang, Woorim Hwang, Yun Su Lee, Seung Hyun Park, Kye Won Kim, Mi Sun Lee, Hyunna Yoon, Hyung Jeong Park, Yoo Kyoung Chalita, Mauricio Lee, Je Hee Sung, Hojun Lee, Jae-Yun Bae, Jin-Woo Chung, Sun Ju |
author_sort | Jo, Sungyang |
collection | PubMed |
description | Although several studies have identified a distinct gut microbial composition in Parkinson’s disease (PD), few studies have investigated the oral microbiome or functional alteration of the microbiome in PD. We aimed to investigate the connection between the oral and gut microbiome and the functional changes in the PD-specific gut microbiome using shotgun metagenomic sequencing. The taxonomic composition of the oral and gut microbiome was significantly different between PD patients and healthy controls (P = 0.003 and 0.001, respectively). Oral Lactobacillus was more abundant in PD patients and was associated with opportunistic pathogens in the gut (FDR-adjusted P < 0.038). Functional analysis revealed that microbial gene markers for glutamate and arginine biosynthesis were downregulated, while antimicrobial resistance gene markers were upregulated in PD patients than healthy controls (all P < 0.001). We identified a connection between the oral and gut microbiota in PD, which might lead to functional alteration of the microbiome in PD. |
format | Online Article Text |
id | pubmed-9262988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-92629882022-07-09 Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease Jo, Sungyang Kang, Woorim Hwang, Yun Su Lee, Seung Hyun Park, Kye Won Kim, Mi Sun Lee, Hyunna Yoon, Hyung Jeong Park, Yoo Kyoung Chalita, Mauricio Lee, Je Hee Sung, Hojun Lee, Jae-Yun Bae, Jin-Woo Chung, Sun Ju NPJ Parkinsons Dis Article Although several studies have identified a distinct gut microbial composition in Parkinson’s disease (PD), few studies have investigated the oral microbiome or functional alteration of the microbiome in PD. We aimed to investigate the connection between the oral and gut microbiome and the functional changes in the PD-specific gut microbiome using shotgun metagenomic sequencing. The taxonomic composition of the oral and gut microbiome was significantly different between PD patients and healthy controls (P = 0.003 and 0.001, respectively). Oral Lactobacillus was more abundant in PD patients and was associated with opportunistic pathogens in the gut (FDR-adjusted P < 0.038). Functional analysis revealed that microbial gene markers for glutamate and arginine biosynthesis were downregulated, while antimicrobial resistance gene markers were upregulated in PD patients than healthy controls (all P < 0.001). We identified a connection between the oral and gut microbiota in PD, which might lead to functional alteration of the microbiome in PD. Nature Publishing Group UK 2022-07-07 /pmc/articles/PMC9262988/ /pubmed/35798742 http://dx.doi.org/10.1038/s41531-022-00351-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Jo, Sungyang Kang, Woorim Hwang, Yun Su Lee, Seung Hyun Park, Kye Won Kim, Mi Sun Lee, Hyunna Yoon, Hyung Jeong Park, Yoo Kyoung Chalita, Mauricio Lee, Je Hee Sung, Hojun Lee, Jae-Yun Bae, Jin-Woo Chung, Sun Ju Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease |
title | Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease |
title_full | Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease |
title_fullStr | Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease |
title_full_unstemmed | Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease |
title_short | Oral and gut dysbiosis leads to functional alterations in Parkinson’s disease |
title_sort | oral and gut dysbiosis leads to functional alterations in parkinson’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262988/ https://www.ncbi.nlm.nih.gov/pubmed/35798742 http://dx.doi.org/10.1038/s41531-022-00351-6 |
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