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Anti-neoplastic action of Cimetidine/Vitamin C on histamine and the PI3K/AKT/mTOR pathway in Ehrlich breast cancer

The main focus of our study is to assess the anti-cancer activity of cimetidine and vitamin C via combating the tumor supportive role of mast cell mediators (histamine, VEGF, and TNF-α) within the tumor microenvironment and their effect on the protein kinase A(PKA)/insulin receptor substrate-1(IRS-1...

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Detalles Bibliográficos
Autores principales:	Ibrahim, Sherihan Salaheldin Abdelhamid, El-Aal, Sarah A. Abd, Reda, Ahmed M., Achy, Samar El, Shahine, Yasmine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262990/ https://www.ncbi.nlm.nih.gov/pubmed/35798765 http://dx.doi.org/10.1038/s41598-022-15551-6

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