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TET1 dioxygenase is required for FOXA2-associated chromatin remodeling in pancreatic beta-cell differentiation

Existing knowledge of the role of epigenetic modifiers in pancreas development has exponentially increased. However, the function of TET dioxygenases in pancreatic endocrine specification remains obscure. We set out to tackle this issue using a human embryonic stem cell (hESC) differentiation system...

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Detalles Bibliográficos
Autores principales:	Li, Jianfang, Wu, Xinwei, Ke, Jie, Lee, Minjung, Lan, Qingping, Li, Jia, Yu, Jianxiu, Huang, Yun, Sun, De-Qiang, Xie, Ruiyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263144/ https://www.ncbi.nlm.nih.gov/pubmed/35798741 http://dx.doi.org/10.1038/s41467-022-31611-x

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