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Aptamer-antibody hybrid ELONA that uses hybridization chain reaction to detect a urinary biomarker EN2 for bladder and prostate cancer

We report an EN2-specific (K(d) = 8.26 nM) aptamer, and a sensitive and specific enzyme-linked oligonucleotide assay (ELONA) for rapid and sensitive colorimetric detection of bladder and prostate cancer biomarker EN2 in urine. The assay relies on an aptamer-mediated hybridization chain reaction (HCR...

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Bibliographic Details
Main Authors:	Kim, Eunseon, Kang, Minji, Ban, Changill
Format:	Online Article Text
Language:	English
Published:	Nature Publishing Group UK 2022
Subjects:	Article
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263169/ https://www.ncbi.nlm.nih.gov/pubmed/35798816 http://dx.doi.org/10.1038/s41598-022-15556-1

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