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Meta-Analysis of the Association Between Asthma and the Risk of Stroke

INTRODUCTION: Asthma and stroke share many risk factors. Previous meta-analysis has indicated that asthma is associated with an increased risk of stroke. However, this study were limited by the small number of articles included and the lack of subgroup analyses of different stroke types and differen...

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Autores principales: Fang, Zheng-Hua, Li, Zhi-Fei, An, Zhuo-Yu, Huang, Si-Cheng, Hao, Meng-Di, Zhang, Wei-Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263265/
https://www.ncbi.nlm.nih.gov/pubmed/35812117
http://dx.doi.org/10.3389/fneur.2022.900438
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author Fang, Zheng-Hua
Li, Zhi-Fei
An, Zhuo-Yu
Huang, Si-Cheng
Hao, Meng-Di
Zhang, Wei-Xing
author_facet Fang, Zheng-Hua
Li, Zhi-Fei
An, Zhuo-Yu
Huang, Si-Cheng
Hao, Meng-Di
Zhang, Wei-Xing
author_sort Fang, Zheng-Hua
collection PubMed
description INTRODUCTION: Asthma and stroke share many risk factors. Previous meta-analysis has indicated that asthma is associated with an increased risk of stroke. However, this study were limited by the small number of articles included and the lack of subgroup analyses of different stroke types and different populations. This meta-analysis aimed to synthesize evidence systematically to investigate the impact of asthma on stroke. METHODS: We searched Medline (via PubMed), Web of Science and EMBASE databases and manually identified eligible studies (inception dates to December 25, 2021) that analyzed the association between asthma and stroke. We conducted quality assessment to evaluate the risk of bias of studies and sensitivity analyses to test the robustness of results. RESULTS: We included 8 cohort studies and 10 cross-sectional studies comprised 3,011,016 participants. We found patients with asthma had a higher risk of stroke than patients without asthma [relative risk (RR): 1.34, 95% confidence interval (CI): 1.21–1.47]. Moreover, asthma significantly increased the risk of ischemic stroke (RR: 1.25, 95% CI: 1.06–1.47) without increasing the risk of hemorrhagic stroke (RR: 1.08, 95% CI: 0.87–1.34). Asthma increased the risk of stroke in both men (RR: 1.20, 95% CI: 1.10–1.32) and women (RR: 1.29, 95% CI: 1.12–1.48) with no significant difference between the sexes. We also found that patients with inactive asthma, child-onset asthma, or no smoking history did not have an increased risk of stroke. CONCLUSIONS: These results supported the finding that asthma could significantly increase the risk of stroke, but this impact was not consistent in different populations. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=290745, identifier: CRD42021290745.
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spelling pubmed-92632652022-07-09 Meta-Analysis of the Association Between Asthma and the Risk of Stroke Fang, Zheng-Hua Li, Zhi-Fei An, Zhuo-Yu Huang, Si-Cheng Hao, Meng-Di Zhang, Wei-Xing Front Neurol Neurology INTRODUCTION: Asthma and stroke share many risk factors. Previous meta-analysis has indicated that asthma is associated with an increased risk of stroke. However, this study were limited by the small number of articles included and the lack of subgroup analyses of different stroke types and different populations. This meta-analysis aimed to synthesize evidence systematically to investigate the impact of asthma on stroke. METHODS: We searched Medline (via PubMed), Web of Science and EMBASE databases and manually identified eligible studies (inception dates to December 25, 2021) that analyzed the association between asthma and stroke. We conducted quality assessment to evaluate the risk of bias of studies and sensitivity analyses to test the robustness of results. RESULTS: We included 8 cohort studies and 10 cross-sectional studies comprised 3,011,016 participants. We found patients with asthma had a higher risk of stroke than patients without asthma [relative risk (RR): 1.34, 95% confidence interval (CI): 1.21–1.47]. Moreover, asthma significantly increased the risk of ischemic stroke (RR: 1.25, 95% CI: 1.06–1.47) without increasing the risk of hemorrhagic stroke (RR: 1.08, 95% CI: 0.87–1.34). Asthma increased the risk of stroke in both men (RR: 1.20, 95% CI: 1.10–1.32) and women (RR: 1.29, 95% CI: 1.12–1.48) with no significant difference between the sexes. We also found that patients with inactive asthma, child-onset asthma, or no smoking history did not have an increased risk of stroke. CONCLUSIONS: These results supported the finding that asthma could significantly increase the risk of stroke, but this impact was not consistent in different populations. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=290745, identifier: CRD42021290745. Frontiers Media S.A. 2022-06-24 /pmc/articles/PMC9263265/ /pubmed/35812117 http://dx.doi.org/10.3389/fneur.2022.900438 Text en Copyright © 2022 Fang, Li, An, Huang, Hao and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Fang, Zheng-Hua
Li, Zhi-Fei
An, Zhuo-Yu
Huang, Si-Cheng
Hao, Meng-Di
Zhang, Wei-Xing
Meta-Analysis of the Association Between Asthma and the Risk of Stroke
title Meta-Analysis of the Association Between Asthma and the Risk of Stroke
title_full Meta-Analysis of the Association Between Asthma and the Risk of Stroke
title_fullStr Meta-Analysis of the Association Between Asthma and the Risk of Stroke
title_full_unstemmed Meta-Analysis of the Association Between Asthma and the Risk of Stroke
title_short Meta-Analysis of the Association Between Asthma and the Risk of Stroke
title_sort meta-analysis of the association between asthma and the risk of stroke
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263265/
https://www.ncbi.nlm.nih.gov/pubmed/35812117
http://dx.doi.org/10.3389/fneur.2022.900438
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