Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB

4-1BB is a T cell costimulatory receptor and a member of the tumor necrosis factor receptor superfamily. Here, we show that Galectin-3 (Gal-3) decreases the cellular response to its ligand (4-1BBL). Gal-3 binds to both soluble 4-1BB (s4-1BB) and membrane-bound 4-1BB (mem4-1BB), without blocking co-b...

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Detalles Bibliográficos
Autores principales: Nielsen, Morten Aagaard, Juul-Madsen, Kristian, Stegmayr, John, Gao, Chao, Mehta, Akul Y., Greisen, Stinne Ravn, Kragstrup, Tue Wenzel, Hvid, Malene, Vorup-Jensen, Thomas, Cummings, Richard D., Leffler, Hakon, Deleuran, Bent Winding
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263355/
https://www.ncbi.nlm.nih.gov/pubmed/35812455
http://dx.doi.org/10.3389/fimmu.2022.915890

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