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DNA N6-Methyladenine Modification in Eukaryotic Genome

DNA methylation is treated as an important epigenetic mark in various biological activities. In the past, a large number of articles focused on 5 mC while lacking attention to N6-methyladenine (6 mA). The presence of 6 mA modification was previously discovered only in prokaryotes. Recently, with the...

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Autores principales: Li, Hao, Zhang, Ning, Wang, Yuechen, Xia, Siyuan, Zhu, Yating, Xing, Chen, Tian, Xuefeng, Du, Yinan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263368/
https://www.ncbi.nlm.nih.gov/pubmed/35812743
http://dx.doi.org/10.3389/fgene.2022.914404
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author Li, Hao
Zhang, Ning
Wang, Yuechen
Xia, Siyuan
Zhu, Yating
Xing, Chen
Tian, Xuefeng
Du, Yinan
author_facet Li, Hao
Zhang, Ning
Wang, Yuechen
Xia, Siyuan
Zhu, Yating
Xing, Chen
Tian, Xuefeng
Du, Yinan
author_sort Li, Hao
collection PubMed
description DNA methylation is treated as an important epigenetic mark in various biological activities. In the past, a large number of articles focused on 5 mC while lacking attention to N6-methyladenine (6 mA). The presence of 6 mA modification was previously discovered only in prokaryotes. Recently, with the development of detection technologies, 6 mA has been found in several eukaryotes, including protozoans, metazoans, plants, and fungi. The importance of 6 mA in prokaryotes and single-celled eukaryotes has been widely accepted. However, due to the incredibly low density of 6 mA and restrictions on detection technologies, the prevalence of 6 mA and its role in biological processes in eukaryotic organisms are highly debated. In this review, we first summarize the advantages and disadvantages of 6 mA detection methods. Then, we conclude existing reports on the prevalence of 6 mA in eukaryotic organisms. Next, we highlight possible methyltransferases, demethylases, and the recognition proteins of 6 mA. In addition, we summarize the functions of 6 mA in eukaryotes. Last but not least, we summarize our point of view and put forward the problems that need further research.
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spelling pubmed-92633682022-07-09 DNA N6-Methyladenine Modification in Eukaryotic Genome Li, Hao Zhang, Ning Wang, Yuechen Xia, Siyuan Zhu, Yating Xing, Chen Tian, Xuefeng Du, Yinan Front Genet Genetics DNA methylation is treated as an important epigenetic mark in various biological activities. In the past, a large number of articles focused on 5 mC while lacking attention to N6-methyladenine (6 mA). The presence of 6 mA modification was previously discovered only in prokaryotes. Recently, with the development of detection technologies, 6 mA has been found in several eukaryotes, including protozoans, metazoans, plants, and fungi. The importance of 6 mA in prokaryotes and single-celled eukaryotes has been widely accepted. However, due to the incredibly low density of 6 mA and restrictions on detection technologies, the prevalence of 6 mA and its role in biological processes in eukaryotic organisms are highly debated. In this review, we first summarize the advantages and disadvantages of 6 mA detection methods. Then, we conclude existing reports on the prevalence of 6 mA in eukaryotic organisms. Next, we highlight possible methyltransferases, demethylases, and the recognition proteins of 6 mA. In addition, we summarize the functions of 6 mA in eukaryotes. Last but not least, we summarize our point of view and put forward the problems that need further research. Frontiers Media S.A. 2022-06-24 /pmc/articles/PMC9263368/ /pubmed/35812743 http://dx.doi.org/10.3389/fgene.2022.914404 Text en Copyright © 2022 Li, Zhang, Wang, Xia, Zhu, Xing, Tian and Du. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Li, Hao
Zhang, Ning
Wang, Yuechen
Xia, Siyuan
Zhu, Yating
Xing, Chen
Tian, Xuefeng
Du, Yinan
DNA N6-Methyladenine Modification in Eukaryotic Genome
title DNA N6-Methyladenine Modification in Eukaryotic Genome
title_full DNA N6-Methyladenine Modification in Eukaryotic Genome
title_fullStr DNA N6-Methyladenine Modification in Eukaryotic Genome
title_full_unstemmed DNA N6-Methyladenine Modification in Eukaryotic Genome
title_short DNA N6-Methyladenine Modification in Eukaryotic Genome
title_sort dna n6-methyladenine modification in eukaryotic genome
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263368/
https://www.ncbi.nlm.nih.gov/pubmed/35812743
http://dx.doi.org/10.3389/fgene.2022.914404
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