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DNA N6-Methyladenine Modification in Eukaryotic Genome
DNA methylation is treated as an important epigenetic mark in various biological activities. In the past, a large number of articles focused on 5 mC while lacking attention to N6-methyladenine (6 mA). The presence of 6 mA modification was previously discovered only in prokaryotes. Recently, with the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263368/ https://www.ncbi.nlm.nih.gov/pubmed/35812743 http://dx.doi.org/10.3389/fgene.2022.914404 |
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author | Li, Hao Zhang, Ning Wang, Yuechen Xia, Siyuan Zhu, Yating Xing, Chen Tian, Xuefeng Du, Yinan |
author_facet | Li, Hao Zhang, Ning Wang, Yuechen Xia, Siyuan Zhu, Yating Xing, Chen Tian, Xuefeng Du, Yinan |
author_sort | Li, Hao |
collection | PubMed |
description | DNA methylation is treated as an important epigenetic mark in various biological activities. In the past, a large number of articles focused on 5 mC while lacking attention to N6-methyladenine (6 mA). The presence of 6 mA modification was previously discovered only in prokaryotes. Recently, with the development of detection technologies, 6 mA has been found in several eukaryotes, including protozoans, metazoans, plants, and fungi. The importance of 6 mA in prokaryotes and single-celled eukaryotes has been widely accepted. However, due to the incredibly low density of 6 mA and restrictions on detection technologies, the prevalence of 6 mA and its role in biological processes in eukaryotic organisms are highly debated. In this review, we first summarize the advantages and disadvantages of 6 mA detection methods. Then, we conclude existing reports on the prevalence of 6 mA in eukaryotic organisms. Next, we highlight possible methyltransferases, demethylases, and the recognition proteins of 6 mA. In addition, we summarize the functions of 6 mA in eukaryotes. Last but not least, we summarize our point of view and put forward the problems that need further research. |
format | Online Article Text |
id | pubmed-9263368 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92633682022-07-09 DNA N6-Methyladenine Modification in Eukaryotic Genome Li, Hao Zhang, Ning Wang, Yuechen Xia, Siyuan Zhu, Yating Xing, Chen Tian, Xuefeng Du, Yinan Front Genet Genetics DNA methylation is treated as an important epigenetic mark in various biological activities. In the past, a large number of articles focused on 5 mC while lacking attention to N6-methyladenine (6 mA). The presence of 6 mA modification was previously discovered only in prokaryotes. Recently, with the development of detection technologies, 6 mA has been found in several eukaryotes, including protozoans, metazoans, plants, and fungi. The importance of 6 mA in prokaryotes and single-celled eukaryotes has been widely accepted. However, due to the incredibly low density of 6 mA and restrictions on detection technologies, the prevalence of 6 mA and its role in biological processes in eukaryotic organisms are highly debated. In this review, we first summarize the advantages and disadvantages of 6 mA detection methods. Then, we conclude existing reports on the prevalence of 6 mA in eukaryotic organisms. Next, we highlight possible methyltransferases, demethylases, and the recognition proteins of 6 mA. In addition, we summarize the functions of 6 mA in eukaryotes. Last but not least, we summarize our point of view and put forward the problems that need further research. Frontiers Media S.A. 2022-06-24 /pmc/articles/PMC9263368/ /pubmed/35812743 http://dx.doi.org/10.3389/fgene.2022.914404 Text en Copyright © 2022 Li, Zhang, Wang, Xia, Zhu, Xing, Tian and Du. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Li, Hao Zhang, Ning Wang, Yuechen Xia, Siyuan Zhu, Yating Xing, Chen Tian, Xuefeng Du, Yinan DNA N6-Methyladenine Modification in Eukaryotic Genome |
title | DNA N6-Methyladenine Modification in Eukaryotic Genome |
title_full | DNA N6-Methyladenine Modification in Eukaryotic Genome |
title_fullStr | DNA N6-Methyladenine Modification in Eukaryotic Genome |
title_full_unstemmed | DNA N6-Methyladenine Modification in Eukaryotic Genome |
title_short | DNA N6-Methyladenine Modification in Eukaryotic Genome |
title_sort | dna n6-methyladenine modification in eukaryotic genome |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263368/ https://www.ncbi.nlm.nih.gov/pubmed/35812743 http://dx.doi.org/10.3389/fgene.2022.914404 |
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