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Task-State Cortical Motor Network Characteristics by Functional Near-Infrared Spectroscopy in Subacute Stroke Show Hemispheric Dominance

BACKGROUND: There was a reorganization of the brain network after stroke. Some studies have compared the characteristics of activation or functional connectivity (FC) of cortical and subcortical regions between the dominant and non-dominant hemisphere stroke. OBJECTIVES: To analyze hemispheric domin...

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Autores principales: Yuan, Ziwen, Xu, Weiwei, Bao, Jiameng, Gao, Hui, Li, Wen, Peng, Yu, Wang, Lisha, Zhao, Ye, Song, Siming, Qiao, Jin, Wang, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263394/
https://www.ncbi.nlm.nih.gov/pubmed/35813955
http://dx.doi.org/10.3389/fnagi.2022.932318
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author Yuan, Ziwen
Xu, Weiwei
Bao, Jiameng
Gao, Hui
Li, Wen
Peng, Yu
Wang, Lisha
Zhao, Ye
Song, Siming
Qiao, Jin
Wang, Gang
author_facet Yuan, Ziwen
Xu, Weiwei
Bao, Jiameng
Gao, Hui
Li, Wen
Peng, Yu
Wang, Lisha
Zhao, Ye
Song, Siming
Qiao, Jin
Wang, Gang
author_sort Yuan, Ziwen
collection PubMed
description BACKGROUND: There was a reorganization of the brain network after stroke. Some studies have compared the characteristics of activation or functional connectivity (FC) of cortical and subcortical regions between the dominant and non-dominant hemisphere stroke. OBJECTIVES: To analyze hemispheric dominance differences in task-state motor network properties in subacute stroke by functional near-infrared spectroscopy (fNIRS). MATERIALS AND METHODS: Patients with first ischemic stroke in the basal ganglia within 1–3 months after onset and age- and sex-matched right-handed healthy subjects (HS) were enrolled. fNIRS with 29 channels was used to detect the oxyhemoglobin concentration changes when performing the hand grasping task. Activation patterns of motor cortex and two macroscale and two mesoscale brain network indicators based on graph theory were compared between dominant and non-dominant hemisphere stroke. RESULTS: We enrolled 17 subjects in each of left hemisphere stroke (LHS), right hemisphere stroke (RHS), and HS groups. Both patient groups showed bilateral activation. The average weighted clustering coefficient and global efficiency of patients were lower than those of healthy people, and the inter-density was higher than that of the HS group, but the significance was different between LHS and RHS groups. The intra-density changes in the RHS group were opposite to those in the LHS group. The correlation between mesoscale indicators and motor function differed between dominant and non-dominant hemisphere stroke. CONCLUSION: The changes in macroscale cortical network indicators were similar between the two patient groups, while those of the mesoscale indicators were different. The mesoscale brain network characteristics were affected by the severity of dysfunction to varying degrees in the LHS and RHS patients.
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spelling pubmed-92633942022-07-09 Task-State Cortical Motor Network Characteristics by Functional Near-Infrared Spectroscopy in Subacute Stroke Show Hemispheric Dominance Yuan, Ziwen Xu, Weiwei Bao, Jiameng Gao, Hui Li, Wen Peng, Yu Wang, Lisha Zhao, Ye Song, Siming Qiao, Jin Wang, Gang Front Aging Neurosci Neuroscience BACKGROUND: There was a reorganization of the brain network after stroke. Some studies have compared the characteristics of activation or functional connectivity (FC) of cortical and subcortical regions between the dominant and non-dominant hemisphere stroke. OBJECTIVES: To analyze hemispheric dominance differences in task-state motor network properties in subacute stroke by functional near-infrared spectroscopy (fNIRS). MATERIALS AND METHODS: Patients with first ischemic stroke in the basal ganglia within 1–3 months after onset and age- and sex-matched right-handed healthy subjects (HS) were enrolled. fNIRS with 29 channels was used to detect the oxyhemoglobin concentration changes when performing the hand grasping task. Activation patterns of motor cortex and two macroscale and two mesoscale brain network indicators based on graph theory were compared between dominant and non-dominant hemisphere stroke. RESULTS: We enrolled 17 subjects in each of left hemisphere stroke (LHS), right hemisphere stroke (RHS), and HS groups. Both patient groups showed bilateral activation. The average weighted clustering coefficient and global efficiency of patients were lower than those of healthy people, and the inter-density was higher than that of the HS group, but the significance was different between LHS and RHS groups. The intra-density changes in the RHS group were opposite to those in the LHS group. The correlation between mesoscale indicators and motor function differed between dominant and non-dominant hemisphere stroke. CONCLUSION: The changes in macroscale cortical network indicators were similar between the two patient groups, while those of the mesoscale indicators were different. The mesoscale brain network characteristics were affected by the severity of dysfunction to varying degrees in the LHS and RHS patients. Frontiers Media S.A. 2022-06-24 /pmc/articles/PMC9263394/ /pubmed/35813955 http://dx.doi.org/10.3389/fnagi.2022.932318 Text en Copyright © 2022 Yuan, Xu, Bao, Gao, Li, Peng, Wang, Zhao, Song, Qiao and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Yuan, Ziwen
Xu, Weiwei
Bao, Jiameng
Gao, Hui
Li, Wen
Peng, Yu
Wang, Lisha
Zhao, Ye
Song, Siming
Qiao, Jin
Wang, Gang
Task-State Cortical Motor Network Characteristics by Functional Near-Infrared Spectroscopy in Subacute Stroke Show Hemispheric Dominance
title Task-State Cortical Motor Network Characteristics by Functional Near-Infrared Spectroscopy in Subacute Stroke Show Hemispheric Dominance
title_full Task-State Cortical Motor Network Characteristics by Functional Near-Infrared Spectroscopy in Subacute Stroke Show Hemispheric Dominance
title_fullStr Task-State Cortical Motor Network Characteristics by Functional Near-Infrared Spectroscopy in Subacute Stroke Show Hemispheric Dominance
title_full_unstemmed Task-State Cortical Motor Network Characteristics by Functional Near-Infrared Spectroscopy in Subacute Stroke Show Hemispheric Dominance
title_short Task-State Cortical Motor Network Characteristics by Functional Near-Infrared Spectroscopy in Subacute Stroke Show Hemispheric Dominance
title_sort task-state cortical motor network characteristics by functional near-infrared spectroscopy in subacute stroke show hemispheric dominance
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263394/
https://www.ncbi.nlm.nih.gov/pubmed/35813955
http://dx.doi.org/10.3389/fnagi.2022.932318
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