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The Association Between Glymphatic System Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease

The mechanism of cognitive impairment in patients with cerebral small vessel disease (CSVD) remains unknown. The glymphatic system dysfunction, which has been demonstrated to influence cognitive impairment, can be evaluated by diffusion tensor image analysis along the perivascular space (ALPS index)...

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Autores principales: Tang, Jie, Zhang, Miaoyi, Liu, Na, Xue, Yang, Ren, Xue, Huang, Qi, Shi, Langfeng, Fu, Jianhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263395/
https://www.ncbi.nlm.nih.gov/pubmed/35813943
http://dx.doi.org/10.3389/fnagi.2022.916633
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author Tang, Jie
Zhang, Miaoyi
Liu, Na
Xue, Yang
Ren, Xue
Huang, Qi
Shi, Langfeng
Fu, Jianhui
author_facet Tang, Jie
Zhang, Miaoyi
Liu, Na
Xue, Yang
Ren, Xue
Huang, Qi
Shi, Langfeng
Fu, Jianhui
author_sort Tang, Jie
collection PubMed
description The mechanism of cognitive impairment in patients with cerebral small vessel disease (CSVD) remains unknown. The glymphatic system dysfunction, which has been demonstrated to influence cognitive impairment, can be evaluated by diffusion tensor image analysis along the perivascular space (ALPS index). We explored whether cognitive impairment in CSVD is associated with glymphatic clearance dysfunction. In this study, 133 patients with CSVD were enrolled and underwent neuropsychological test batteries as well as magnetic resonance imaging (MRI). They were then categorized into a CSVD with cognitive impairment (CSVD-CI) group and a cognitively normal CSVD (CSVD-CN) group. The ALPS index and four CSVD markers [white matter lesions (WMLs), cerebral microbleeds (CMBs), lacunes, and perivascular spaces (PVSs)] were also assessed. Univariate analysis showed that the ALPS index was significantly different between the CSVD-CN (n = 50) and CSVD-CI groups (n = 83) (p < 0.001). This difference remained significant (95% CI < 0.001–0.133) after adjusting for six common risk factors (age, education, hypertension, diabetes, smoking, and alcohol abuse) as well as CSVD markers. The ALPS index was independently linearly correlated with global cognitive function, executive function, attention function, and memory after adjusting for the aforementioned six risk factors or CSVD markers. Our results suggest that glymphatic system impairment is independently related to cognitive impairment in patients with CSVD.
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spelling pubmed-92633952022-07-09 The Association Between Glymphatic System Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease Tang, Jie Zhang, Miaoyi Liu, Na Xue, Yang Ren, Xue Huang, Qi Shi, Langfeng Fu, Jianhui Front Aging Neurosci Aging Neuroscience The mechanism of cognitive impairment in patients with cerebral small vessel disease (CSVD) remains unknown. The glymphatic system dysfunction, which has been demonstrated to influence cognitive impairment, can be evaluated by diffusion tensor image analysis along the perivascular space (ALPS index). We explored whether cognitive impairment in CSVD is associated with glymphatic clearance dysfunction. In this study, 133 patients with CSVD were enrolled and underwent neuropsychological test batteries as well as magnetic resonance imaging (MRI). They were then categorized into a CSVD with cognitive impairment (CSVD-CI) group and a cognitively normal CSVD (CSVD-CN) group. The ALPS index and four CSVD markers [white matter lesions (WMLs), cerebral microbleeds (CMBs), lacunes, and perivascular spaces (PVSs)] were also assessed. Univariate analysis showed that the ALPS index was significantly different between the CSVD-CN (n = 50) and CSVD-CI groups (n = 83) (p < 0.001). This difference remained significant (95% CI < 0.001–0.133) after adjusting for six common risk factors (age, education, hypertension, diabetes, smoking, and alcohol abuse) as well as CSVD markers. The ALPS index was independently linearly correlated with global cognitive function, executive function, attention function, and memory after adjusting for the aforementioned six risk factors or CSVD markers. Our results suggest that glymphatic system impairment is independently related to cognitive impairment in patients with CSVD. Frontiers Media S.A. 2022-06-24 /pmc/articles/PMC9263395/ /pubmed/35813943 http://dx.doi.org/10.3389/fnagi.2022.916633 Text en Copyright © 2022 Tang, Zhang, Liu, Xue, Ren, Huang, Shi and Fu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Tang, Jie
Zhang, Miaoyi
Liu, Na
Xue, Yang
Ren, Xue
Huang, Qi
Shi, Langfeng
Fu, Jianhui
The Association Between Glymphatic System Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease
title The Association Between Glymphatic System Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease
title_full The Association Between Glymphatic System Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease
title_fullStr The Association Between Glymphatic System Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease
title_full_unstemmed The Association Between Glymphatic System Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease
title_short The Association Between Glymphatic System Dysfunction and Cognitive Impairment in Cerebral Small Vessel Disease
title_sort association between glymphatic system dysfunction and cognitive impairment in cerebral small vessel disease
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263395/
https://www.ncbi.nlm.nih.gov/pubmed/35813943
http://dx.doi.org/10.3389/fnagi.2022.916633
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