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Increased LDL receptor by SREBP2 or SREBP2-induced lncRNA LDLR-AS promotes triglyceride accumulation in fish

LDLR, as the uptake receptor of low-density lipoprotein, plays a crucial role in lipid metabolism. However, the detailed mechanism by which LDLR affects hepatic triglyceride (TG) accumulation has rarely been reported. Here, we found that knockdown of LDLR effectively mitigated PA-induced TG accumula...

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Detalles Bibliográficos
Autores principales: Cao, Xiufei, Fang, Wei, Li, Xueshan, Wang, Xiuneng, Mai, Kangsen, Ai, Qinghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263516/
https://www.ncbi.nlm.nih.gov/pubmed/35811843
http://dx.doi.org/10.1016/j.isci.2022.104670