Pre-clinic study of radiopharmaceutical for Covid-19 inactivation: Dose distribution with Monte Carlo Simulation

Monte Carlo simulation method and Nuclear Medicine MIRD method were used to evaluate the effect of radiopharmaceuticals on Covid-19 disease. The mean absorbed organ dose in the target organ and gamma radiation emitter attenuation properties such as linear attenuation coefficients, energy absorption...

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Autores principales: Kilicoglu, Ozge, Kara, Umit, Ozgenc, Emre, Gundogdu, Evren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263601/
https://www.ncbi.nlm.nih.gov/pubmed/35839712
http://dx.doi.org/10.1016/j.apradiso.2022.110364
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author Kilicoglu, Ozge
Kara, Umit
Ozgenc, Emre
Gundogdu, Evren
author_facet Kilicoglu, Ozge
Kara, Umit
Ozgenc, Emre
Gundogdu, Evren
author_sort Kilicoglu, Ozge
collection PubMed
description Monte Carlo simulation method and Nuclear Medicine MIRD method were used to evaluate the effect of radiopharmaceuticals on Covid-19 disease. The mean absorbed organ dose in the target organ and gamma radiation emitter attenuation properties such as linear attenuation coefficients, energy absorption build-up factors (EABF), exposure build-up factors (EBF), and relative dose distributions (RDD) were examined. The results showed that radiopharmaceuticals containing gamma radiation emitters which are densely ionizing charged particles induced membrane damage and produced protein damage.
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spelling pubmed-92636012022-07-08 Pre-clinic study of radiopharmaceutical for Covid-19 inactivation: Dose distribution with Monte Carlo Simulation Kilicoglu, Ozge Kara, Umit Ozgenc, Emre Gundogdu, Evren Appl Radiat Isot Article Monte Carlo simulation method and Nuclear Medicine MIRD method were used to evaluate the effect of radiopharmaceuticals on Covid-19 disease. The mean absorbed organ dose in the target organ and gamma radiation emitter attenuation properties such as linear attenuation coefficients, energy absorption build-up factors (EABF), exposure build-up factors (EBF), and relative dose distributions (RDD) were examined. The results showed that radiopharmaceuticals containing gamma radiation emitters which are densely ionizing charged particles induced membrane damage and produced protein damage. Elsevier Ltd. 2022-10 2022-07-08 /pmc/articles/PMC9263601/ /pubmed/35839712 http://dx.doi.org/10.1016/j.apradiso.2022.110364 Text en © 2022 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Kilicoglu, Ozge
Kara, Umit
Ozgenc, Emre
Gundogdu, Evren
Pre-clinic study of radiopharmaceutical for Covid-19 inactivation: Dose distribution with Monte Carlo Simulation
title Pre-clinic study of radiopharmaceutical for Covid-19 inactivation: Dose distribution with Monte Carlo Simulation
title_full Pre-clinic study of radiopharmaceutical for Covid-19 inactivation: Dose distribution with Monte Carlo Simulation
title_fullStr Pre-clinic study of radiopharmaceutical for Covid-19 inactivation: Dose distribution with Monte Carlo Simulation
title_full_unstemmed Pre-clinic study of radiopharmaceutical for Covid-19 inactivation: Dose distribution with Monte Carlo Simulation
title_short Pre-clinic study of radiopharmaceutical for Covid-19 inactivation: Dose distribution with Monte Carlo Simulation
title_sort pre-clinic study of radiopharmaceutical for covid-19 inactivation: dose distribution with monte carlo simulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263601/
https://www.ncbi.nlm.nih.gov/pubmed/35839712
http://dx.doi.org/10.1016/j.apradiso.2022.110364
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