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Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of S. aureus Osteomyelitis: Evidence of “Target & Release” Kinetics and Killing of Bacteria Within Canaliculi

S. aureus infection of bone is difficult to eradicate due to its ability to colonize the osteocyte-lacuno-canalicular network (OLCN), rendering it resistant to standard-of-care (SOC) antibiotics. To overcome this, we proposed two bone-targeted bisphosphonate-conjugated antibiotics (BCA): bisphosphon...

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Detalles Bibliográficos
Autores principales:	Ren, Youliang, Xue, Thomas, Rainbolt, Joshua, Bentley, Karen L. de Mesy, Galloway, Chad A., Liu, Yuting, Cherian, Philip, Neighbors, Jeffrey, Hofstee, Marloes I., Ebetino, Frank H., Moriarty, Thomas Fintan, Sun, Shuting, Schwarz, Edward M., Xie, Chao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263620/ https://www.ncbi.nlm.nih.gov/pubmed/35811672 http://dx.doi.org/10.3389/fcimb.2022.910970

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