Gut microbiota and host Cyp450s co-contribute to pharmacokinetic variability in mice with non-alcoholic steatohepatitis: Effects vary from drug to drug

INTRODUCTION: Pharmacokinetic variability in disease state is common in clinical practice, but its underlying mechanism remains unclear. Recently, gut microbiota has been considered to be pharmacokinetically equivalent to the host liver. Although some studies have explored the roles of gut microbiot...

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Detalles Bibliográficos
Autores principales: Guo, Jing, Xu, Ying, Chen, Li-jie, Zhang, Song-xia, Liou, Yu-ligh, Chen, Xiao-ping, Tan, Zhi-rong, Zhou, Hong-hao, Zhang, Wei, Chen, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Pharmaceutical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263650/
https://www.ncbi.nlm.nih.gov/pubmed/35777915
http://dx.doi.org/10.1016/j.jare.2021.10.004

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