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The generation of stem cell-like memory cells early after BNT162b2 vaccination is associated with durability of memory CD8(+) T cell responses
COVID-19 vaccines elicit humoral and cellular immune responses. Durable maintenance of vaccine-induced immunity is required for long-term protection of the host. Here, we examine activation and differentiation of vaccine-induced CD8(+) T cells using MHC class I (MHC-I) multimers and correlations bet...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s).
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263810/ https://www.ncbi.nlm.nih.gov/pubmed/35839774 http://dx.doi.org/10.1016/j.celrep.2022.111138 |
Sumario: | COVID-19 vaccines elicit humoral and cellular immune responses. Durable maintenance of vaccine-induced immunity is required for long-term protection of the host. Here, we examine activation and differentiation of vaccine-induced CD8(+) T cells using MHC class I (MHC-I) multimers and correlations between early differentiation and the durability of CD8(+) T cell responses among healthcare workers immunized with two doses of BNT162b2. The frequency of MHC-I multimer(+) cells is robustly increased by BNT162b2 but decreases 6 months post-second vaccination to 2.4%–65.6% (23.0% on average) of the peak. MHC-I multimer(+) cells dominantly exhibit phenotypes of activated effector cells 1–2 weeks post-second vaccination and gradually acquire phenotypes of long-term memory cells, including stem cell-like memory T (T(SCM)) cells. Importantly, the frequency of T(SCM) cells 1–2 weeks post-second vaccination significantly correlates with the 6-month durability of CD8(+) T cells, indicating that early generation of T(SCM) cells determines the longevity of vaccine-induced memory CD8(+) T cell responses. |
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