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Carbon ion radiotherapy for unresectable primary undifferentiated pleomorphic sarcoma of the 11th thoracic spine: a case report
Objective: Primary undifferentiated pleomorphic sarcoma (UPS) of the bone is rare. However, the common sites are the knee and proximal femur and humerus, while spinal involvement is rare. We report a case of primary UPS of the 11th thoracic vertebra, where corpectomy would have been difficult and ex...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Japanese Association of Rural Medicine
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263953/ https://www.ncbi.nlm.nih.gov/pubmed/35847761 http://dx.doi.org/10.2185/jrm.2021-049 |
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author | Murase, Fuminori Nakashima, Hiroatsu Ito, Kenyu Demizu, Yusuke Takatsu, Tetsuro |
author_facet | Murase, Fuminori Nakashima, Hiroatsu Ito, Kenyu Demizu, Yusuke Takatsu, Tetsuro |
author_sort | Murase, Fuminori |
collection | PubMed |
description | Objective: Primary undifferentiated pleomorphic sarcoma (UPS) of the bone is rare. However, the common sites are the knee and proximal femur and humerus, while spinal involvement is rare. We report a case of primary UPS of the 11th thoracic vertebra, where corpectomy would have been difficult and extensive, treated with carbon ion radiotherapy. Case report: A 76-year-old man presented with an osteolytic tumor of the 11th thoracic vertebra on plain computed tomography (CT). The spinal cord was compressed and displaced posteriorly by the tumor on magnetic resonance imaging (MRI), and extraosseous extension was observed. An incisional biopsy was performed, and primary UPS of the 11th thoracic vertebra was diagnosed pathologically. Total en bloc spondylectomy was considered to be challenging because of the extraosseous extension and the patient’s age; thus, carbon ion radiotherapy (70.4 GyE / 32 fraction) was performed. Denosumab (120 mg) was administered subcutaneously every four weeks. No adjuvant chemotherapy was administered. Four years post-treatment, imaging revealed a compression fracture of the 11th thoracic vertebra, but there was no recurrence. Conclusion: Despite a poor prognosis and an aggressive course of UPS of the spine, the tumor continues to be controlled without local recurrence four years after carbon ion radiotherapy. |
format | Online Article Text |
id | pubmed-9263953 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Japanese Association of Rural Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-92639532022-07-14 Carbon ion radiotherapy for unresectable primary undifferentiated pleomorphic sarcoma of the 11th thoracic spine: a case report Murase, Fuminori Nakashima, Hiroatsu Ito, Kenyu Demizu, Yusuke Takatsu, Tetsuro J Rural Med Case Report Objective: Primary undifferentiated pleomorphic sarcoma (UPS) of the bone is rare. However, the common sites are the knee and proximal femur and humerus, while spinal involvement is rare. We report a case of primary UPS of the 11th thoracic vertebra, where corpectomy would have been difficult and extensive, treated with carbon ion radiotherapy. Case report: A 76-year-old man presented with an osteolytic tumor of the 11th thoracic vertebra on plain computed tomography (CT). The spinal cord was compressed and displaced posteriorly by the tumor on magnetic resonance imaging (MRI), and extraosseous extension was observed. An incisional biopsy was performed, and primary UPS of the 11th thoracic vertebra was diagnosed pathologically. Total en bloc spondylectomy was considered to be challenging because of the extraosseous extension and the patient’s age; thus, carbon ion radiotherapy (70.4 GyE / 32 fraction) was performed. Denosumab (120 mg) was administered subcutaneously every four weeks. No adjuvant chemotherapy was administered. Four years post-treatment, imaging revealed a compression fracture of the 11th thoracic vertebra, but there was no recurrence. Conclusion: Despite a poor prognosis and an aggressive course of UPS of the spine, the tumor continues to be controlled without local recurrence four years after carbon ion radiotherapy. The Japanese Association of Rural Medicine 2022-07-01 2022-07 /pmc/articles/PMC9263953/ /pubmed/35847761 http://dx.doi.org/10.2185/jrm.2021-049 Text en ©2022 The Japanese Association of Rural Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Case Report Murase, Fuminori Nakashima, Hiroatsu Ito, Kenyu Demizu, Yusuke Takatsu, Tetsuro Carbon ion radiotherapy for unresectable primary undifferentiated pleomorphic sarcoma of the 11th thoracic spine: a case report |
title | Carbon ion radiotherapy for unresectable primary undifferentiated pleomorphic
sarcoma of the 11th thoracic spine: a case report |
title_full | Carbon ion radiotherapy for unresectable primary undifferentiated pleomorphic
sarcoma of the 11th thoracic spine: a case report |
title_fullStr | Carbon ion radiotherapy for unresectable primary undifferentiated pleomorphic
sarcoma of the 11th thoracic spine: a case report |
title_full_unstemmed | Carbon ion radiotherapy for unresectable primary undifferentiated pleomorphic
sarcoma of the 11th thoracic spine: a case report |
title_short | Carbon ion radiotherapy for unresectable primary undifferentiated pleomorphic
sarcoma of the 11th thoracic spine: a case report |
title_sort | carbon ion radiotherapy for unresectable primary undifferentiated pleomorphic
sarcoma of the 11th thoracic spine: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263953/ https://www.ncbi.nlm.nih.gov/pubmed/35847761 http://dx.doi.org/10.2185/jrm.2021-049 |
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