Cargando…

Dysregulation of Neuropeptide and Tau Peptide Signatures in Human Alzheimer’s Disease Brain

[Image: see text] Synaptic dysfunction and loss occur in Alzheimer’s disease (AD) brains, which results in cognitive deficits and brain neurodegeneration. Neuropeptides comprise the major group of synaptic neurotransmitters in the nervous system. This study evaluated neuropeptide signatures that are...

Descripción completa

Detalles Bibliográficos
Autores principales:	Podvin, Sonia, Jiang, Zhenze, Boyarko, Ben, Rossitto, Leigh-Ana, O’Donoghue, Anthony, Rissman, Robert A., Hook, Vivian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264367/ https://www.ncbi.nlm.nih.gov/pubmed/35758417 http://dx.doi.org/10.1021/acschemneuro.2c00222

Ejemplares similares

Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases
por: Yoon, Michael C., et al.
Publicado: (2022)

Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses
por: Podvin, Sonia, et al.
Publicado: (2020)

Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration
por: Boyarko, Ben, et al.
Publicado: (2021)

Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons
por: Podvin, Sonia, et al.
Publicado: (2021)

Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing
por: Jiang, Zhenze, et al.
Publicado: (2021)

Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production
por: Podvin, Sonia, et al.
Publicado: (2018)

Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range
por: Yoon, Michael C., et al.
Publicado: (2023)

Evaluation of bumetanide as a potential therapeutic agent for Alzheimer’s disease
por: Boyarko, Ben, et al.
Publicado: (2023)

Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington’s Disease
por: Podvin, Sonia, et al.
Publicado: (2022)

Cathepsin B Dipeptidyl Carboxypeptidase and Endopeptidase Activities Demonstrated across a Broad pH Range
por: Yoon, Michael C., et al.
Publicado: (2022)

Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia
por: Campeau, Anaamika, et al.
Publicado: (2021)

High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma
por: Maffioli, Elisa, et al.
Publicado: (2020)

Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation
por: Park, Jun Sung, et al.
Publicado: (2019)

Neuropeptides Exert Neuroprotective Effects in Alzheimer's Disease
por: Chen, Xin-Yi, et al.
Publicado: (2019)

Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease
por: Roda, Alejandro R., et al.
Publicado: (2022)

Tau Aggregation Inhibiting Peptides as Potential Therapeutics for Alzheimer Disease
por: Aillaud, Isabelle, et al.
Publicado: (2022)

ProSAAS-Derived Peptides are Colocalized with Neuropeptide Y and Function as Neuropeptides in the Regulation of Food Intake
por: Wardman, Jonathan H., et al.
Publicado: (2011)

Neuropeptide delivery to the brain: a von Willebrand factor signal peptide to direct neuropeptide secretion
por: de Backer, Marijke WA, et al.
Publicado: (2010)

Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer’s disease
por: Pascoal, Tharick A., et al.
Publicado: (2018)

Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s disease
por: Ferrari-Souza, João Pedro, et al.
Publicado: (2022)

Implications of Tau Dysregulation in Huntington’s Disease and Potential for New Therapeutics
por: Mees, Isaline, et al.
Publicado: (2023)

Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer’s disease
por: Canobbio, Ilaria, et al.
Publicado: (2015)

Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions
por: Phan, Von V., et al.
Publicado: (2022)

Peptide Interference with APP and Tau Association: Relevance to Alzheimer’s Disease Amelioration
por: Maron, Ruth, et al.
Publicado: (2020)

Regulation of ecdysone production in Drosophila by neuropeptides and peptide hormones
por: Kannangara, Jade R., et al.
Publicado: (2021)

Tau-Mediated Dysregulation of Neuroplasticity and Glial Plasticity
por: Koller, Emily J., et al.
Publicado: (2020)

Dysregulation of antimicrobial peptide expression distinguishes Alzheimer’s disease from normal aging
por: Wang, Min, et al.
Publicado: (2020)

Transcriptional Signatures of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer’s Disease
por: Stein-O’Brien, Genevieve L, et al.
Publicado: (2023)

Distinct Molecular Signatures of Amyloid-Beta and Tau in Alzheimer’s Disease Associated with Down Syndrome
por: Ichimata, Shojiro, et al.
Publicado: (2023)

Somatostatin and Neuropeptide Y in Cerebrospinal Fluid: Correlations With Amyloid Peptides Aβ(1–42) and Tau Proteins in Elderly Patients With Mild Cognitive Impairment
por: Duron, Emmanuelle, et al.
Publicado: (2018)

Corrigendum: Somatostatin and Neuropeptide Y in Cerebrospinal Fluid: Correlations With Amyloid Peptides Aß(1−42), and Tau Proteins in Elderly Patients With Mild Cognitive Impairment
por: Duron, Emmanuelle, et al.
Publicado: (2019)

Central and peripheral significance of neuropeptide Y and its related peptides /
Publicado: (1990)

Neuropeptide Y Peptide Family and Cancer: Antitumor Therapeutic Strategies
por: Sánchez, Manuel Lisardo, et al.
Publicado: (2023)

A toxin-based approach to neuropeptide and peptide hormone discovery
por: Koch, Thomas Lund, et al.
Publicado: (2023)

Reproductive status impact on tau phosphorylation induced by chronic stress
por: Muñoz-Mayorga, Daniel, et al.
Publicado: (2020)

Subclinical lipopolysaccharide from Salmonella Enteritidis induces neuropeptide dysregulation in the spinal cord and the dorsal root ganglia
por: Mikołajczyk, Anita, et al.
Publicado: (2019)

Modulation of Amyloid-β and Tau in Alzheimer’s Disease Plasma Neuronal-Derived Extracellular Vesicles by Cerebrolysin® and Donepezil
por: Alvarez, X. Anton, et al.
Publicado: (2022)

Cerebrospinal Fluid and Brain Proteoforms of the Granin Neuropeptide Family in Alzheimer’s Disease
por: Quinn, James P., et al.
Publicado: (2023)

Calpain Dysregulation in Alzheimer's Disease
por: Ferreira, Adriana
Publicado: (2012)

Selection and Characterization of Tau Binding ᴅ-Enantiomeric Peptides with Potential for Therapy of Alzheimer Disease
por: Dammers, Christina, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_m7rj1rm511lul413r9iptu1og4