Structural Analysis and Development of Notum Fragment Screening Hits

[Image: see text] The Wnt signaling suppressor Notum is a promising target for osteoporosis, Alzheimer’s disease, and colorectal cancers. To develop novel Notum inhibitors, we used an X-ray crystallographic fragment screen with the Diamond-SGC Poised Library (DSPL) and identified 59 fragment hits fr...

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Detalles Bibliográficos
Autores principales: Zhao, Yuguang, Mahy, William, Willis, Nicky J., Woodward, Hannah L., Steadman, David, Bayle, Elliott D., Atkinson, Benjamin N., Sipthorp, James, Vecchia, Luca, Ruza, Reinis R., Harlos, Karl, Jeganathan, Fiona, Constantinou, Stefan, Costa, Artur, Kjær, Svend, Bictash, Magda, Salinas, Patricia C., Whiting, Paul, Vincent, Jean-Paul, Fish, Paul V., Jones, E. Yvonne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264368/
https://www.ncbi.nlm.nih.gov/pubmed/35731924
http://dx.doi.org/10.1021/acschemneuro.2c00325

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