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Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling

BACKGROUND: Autophagy dysfunction plays a crucial role in tau accumulation and neurodegeneration in Alzheimer’s disease (AD). This study aimed to investigate whether and how the accumulating tau may in turn affect autophagy. METHODS: The primary hippocampal neurons, N2a and HEK293T cells with tau ov...

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Detalles Bibliográficos
Autores principales:	Li, Meng-Zhu, Liu, En-Jie, Zhou, Qiu-Zhi, Li, Shi-Hong, Liu, Shi-Jie, Yu, Hai-Tao, Pan, Qi-Hang, Sun, Fei, He, Ting, Wang, Wei-Jin, Ke, Dan, Feng, Yu-Qi, Li, Jun, Wang, Jian-Zhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264508/ https://www.ncbi.nlm.nih.gov/pubmed/35799293 http://dx.doi.org/10.1186/s40779-022-00396-x

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