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Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors
The development of combination immunotherapy based on the mediation of regulatory mechanisms of the tumor immune microenvironment (TIME) is promising. However, a deep understanding of tumor immunology must involve the systemic tumor immune environment (STIE) which was merely illustrated previously....
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264569/ https://www.ncbi.nlm.nih.gov/pubmed/35799264 http://dx.doi.org/10.1186/s13045-022-01307-2 |
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author | Xu, Liangliang Zou, Chang Zhang, Shanshan Chu, Timothy Shun Man Zhang, Yan Chen, Weiwei Zhao, Caining Yang, Li Xu, Zhiyuan Dong, Shaowei Yu, Hao Li, Bo Guan, Xinyuan Hou, Yuzhu Kong, Feng-Ming |
author_facet | Xu, Liangliang Zou, Chang Zhang, Shanshan Chu, Timothy Shun Man Zhang, Yan Chen, Weiwei Zhao, Caining Yang, Li Xu, Zhiyuan Dong, Shaowei Yu, Hao Li, Bo Guan, Xinyuan Hou, Yuzhu Kong, Feng-Ming |
author_sort | Xu, Liangliang |
collection | PubMed |
description | The development of combination immunotherapy based on the mediation of regulatory mechanisms of the tumor immune microenvironment (TIME) is promising. However, a deep understanding of tumor immunology must involve the systemic tumor immune environment (STIE) which was merely illustrated previously. Here, we aim to review recent advances in single-cell transcriptomics and spatial transcriptomics for the studies of STIE, TIME, and their interactions, which may reveal heterogeneity in immunotherapy responses as well as the dynamic changes essential for the treatment effect. We review the evidence from preclinical and clinical studies related to TIME, STIE, and their significance on overall survival, through different immunomodulatory pathways, such as metabolic and neuro-immunological pathways. We also evaluate the significance of the STIE, TIME, and their interactions as well as changes after local radiotherapy and systemic immunotherapy or combined immunotherapy. We focus our review on the evidence of lung cancer, hepatocellular carcinoma, and nasopharyngeal carcinoma, aiming to reshape STIE and TIME to enhance immunotherapy efficacy. |
format | Online Article Text |
id | pubmed-9264569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-92645692022-07-09 Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors Xu, Liangliang Zou, Chang Zhang, Shanshan Chu, Timothy Shun Man Zhang, Yan Chen, Weiwei Zhao, Caining Yang, Li Xu, Zhiyuan Dong, Shaowei Yu, Hao Li, Bo Guan, Xinyuan Hou, Yuzhu Kong, Feng-Ming J Hematol Oncol Review The development of combination immunotherapy based on the mediation of regulatory mechanisms of the tumor immune microenvironment (TIME) is promising. However, a deep understanding of tumor immunology must involve the systemic tumor immune environment (STIE) which was merely illustrated previously. Here, we aim to review recent advances in single-cell transcriptomics and spatial transcriptomics for the studies of STIE, TIME, and their interactions, which may reveal heterogeneity in immunotherapy responses as well as the dynamic changes essential for the treatment effect. We review the evidence from preclinical and clinical studies related to TIME, STIE, and their significance on overall survival, through different immunomodulatory pathways, such as metabolic and neuro-immunological pathways. We also evaluate the significance of the STIE, TIME, and their interactions as well as changes after local radiotherapy and systemic immunotherapy or combined immunotherapy. We focus our review on the evidence of lung cancer, hepatocellular carcinoma, and nasopharyngeal carcinoma, aiming to reshape STIE and TIME to enhance immunotherapy efficacy. BioMed Central 2022-07-07 /pmc/articles/PMC9264569/ /pubmed/35799264 http://dx.doi.org/10.1186/s13045-022-01307-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Xu, Liangliang Zou, Chang Zhang, Shanshan Chu, Timothy Shun Man Zhang, Yan Chen, Weiwei Zhao, Caining Yang, Li Xu, Zhiyuan Dong, Shaowei Yu, Hao Li, Bo Guan, Xinyuan Hou, Yuzhu Kong, Feng-Ming Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors |
title | Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors |
title_full | Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors |
title_fullStr | Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors |
title_full_unstemmed | Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors |
title_short | Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors |
title_sort | reshaping the systemic tumor immune environment (stie) and tumor immune microenvironment (time) to enhance immunotherapy efficacy in solid tumors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264569/ https://www.ncbi.nlm.nih.gov/pubmed/35799264 http://dx.doi.org/10.1186/s13045-022-01307-2 |
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