Cargando…

Identification of a cytokine-dominated immunosuppressive class in squamous cell lung carcinoma with implications for immunotherapy resistance

BACKGROUND: Immune checkpoint blockade (ICB) therapy has revolutionized the treatment of lung squamous cell carcinoma (LUSC). However, a significant proportion of patients with high tumour PD-L1 expression remain resistant to immune checkpoint inhibitors. To understand the underlying resistance mech...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Minglei, Lin, Chenghao, Wang, Yanni, Chen, Kang, Zhang, Haiyue, Li, Weizhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264601/ https://www.ncbi.nlm.nih.gov/pubmed/35799269 http://dx.doi.org/10.1186/s13073-022-01079-x

Ejemplares similares

Cytokine storm promoting T cell exhaustion in severe COVID-19 revealed by single cell sequencing data analysis
por: Yang, Minglei, et al.
Publicado: (2022)

Multi-omic analysis characterizes molecular susceptibility of receptors to SARS-CoV-2 spike protein
por: Wu, Fanjie, et al.
Publicado: (2023)

S100A7 attenuates immunotherapy by enhancing immunosuppressive tumor microenvironment in lung squamous cell carcinoma
por: Liu, Chengming, et al.
Publicado: (2022)

Identification of TREM2-positive tumor-associated macrophages in esophageal squamous cell carcinoma: implication for poor prognosis and immunotherapy modulation
por: Li, Hongmu, et al.
Publicado: (2023)

Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy
por: Giles, Amber J., et al.
Publicado: (2018)

Mapping the immunosuppressive environment in uterine tumors: implications for immunotherapy
por: Vanderstraeten, Anke, et al.
Publicado: (2014)

Combined alignments of sequences and domains characterize unknown proteins with remotely related protein search PSISearch2D
por: Yang, Minglei, et al.
Publicado: (2019)

Identification of neoantigen-specific T cells and their targets: implications for immunotherapy of head and neck squamous cell carcinoma
por: Ren, Lili, et al.
Publicado: (2019)

Cancer immunotherapy by immunosuppression
por: Prehn, Richmond T, et al.
Publicado: (2010)

Immunosuppressive mechanisms of oncofetal reprogramming in the tumor microenvironment: implications in immunotherapy response
por: Currenti, Jennifer, et al.
Publicado: (2023)

Multi-omics analysis to identify lung squamous carcinoma lactate metabolism-related subtypes and establish related index to predict prognosis and guide immunotherapy
por: Wang, Chenghao, et al.
Publicado: (2022)

Identification and Validation of the Immune Subtypes of Lung Adenocarcinoma: Implications for Immunotherapy
por: Song, Yang, et al.
Publicado: (2020)

What Dominates the Female Class Identification? Evidence From China
por: Cheng, Peng, et al.
Publicado: (2021)

Role of the immunosuppressive microenvironment in immunotherapy
por: Tormoen, Garth W., et al.
Publicado: (2018)

Clinicopathological implications of lncRNAs, immunotherapy and DNA methylation in lung squamous cell carcinoma: a narrative review
por: Sasa, Gabriel B. K., et al.
Publicado: (2021)

Keratoacanthomas have an immunosuppressive cytokine environment of increased IL-10 and decreased GM-CSF compared to squamous cell carcinomas
por: Lowes, M A, et al.
Publicado: (1999)

Immunosuppressive dead cell as lung-targeting vehicle and cytokine absorption material for cytokine storm attenuation of pneumonia
por: Ci, Tianyuan, et al.
Publicado: (2023)

Identification of biomarkers for immunotherapy response in prostate cancer and potential drugs to alleviate immunosuppression
por: Zhang, Jinpeng, et al.
Publicado: (2022)

Tumor-Derived Exosomes in Immunosuppression and Immunotherapy
por: Olejarz, Wioletta, et al.
Publicado: (2020)

The immunosuppressive microenvironment and immunotherapy in human glioblastoma
por: Zhang, Xuehua, et al.
Publicado: (2022)

Unmet needs in squamous cell carcinoma of the lung: potential role for immunotherapy
por: Stinchcombe, Thomas E.
Publicado: (2014)

Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development
por: Figueiredo, Carlos R, et al.
Publicado: (2020)

Identification of prognostic aging-related genes associated with immunosuppression and inflammation in head and neck squamous cell carcinoma
por: Yang, Jing, et al.
Publicado: (2020)

The Role of Cytokines and Chemokines in Shaping the Immune Microenvironment of Glioblastoma: Implications for Immunotherapy
por: Yeo, Erica C. F., et al.
Publicado: (2021)

Identification and validation of RNA‐binding protein‐related gene signature revealed potential associations with immunosuppression and drug sensitivity in glioma
por: Chen, Zhuohui, et al.
Publicado: (2021)

Identification of immunotherapy biomarkers for improving the clinical outcome of homologous recombination deficiency patients with lung adenocarcinoma
por: Zhou, Xiang, et al.
Publicado: (2023)

Multiple-Cytokine Profiling: A Novel Method for Early Prediction of the Efficacy of Sublingual Immunotherapy in Allergic Rhinitis Patients
por: Zhang, Yanni, et al.
Publicado: (2022)

Identification of JAK2 and FOXM1 expression as novel candidate biomarkers for predicting the benefit of immunotherapy in lung squamous cell carcinoma
por: Zhang, Shixin, et al.
Publicado: (2021)

MicroPhenoDB Associates Metagenomic Data with Pathogenic Microbes, Microbial Core Genes, and Human Disease Phenotypes
por: Yao, Guocai, et al.
Publicado: (2020)

Cytokines in Cancer Immunotherapy
por: Lee, Sylvia, et al.
Publicado: (2011)

Immunotherapy for Esophageal Squamous Cell Carcinoma
por: Kojima, Takashi, et al.
Publicado: (2017)

Cytokine cascade and networks among MSM HIV seroconverters: implications for early immunotherapy
por: Huang, Xiaojie, et al.
Publicado: (2016)

Identification of genomic determinants contributing to cytokine release in immunotherapies and human diseases
por: Shao, Lipei, et al.
Publicado: (2022)

Identification of immune subtypes of cervical squamous cell carcinoma predicting prognosis and immunotherapy responses
por: Li, Yimin, et al.
Publicado: (2021)

Deep learning-based six-type classifier for lung cancer and mimics from histopathological whole slide images: a retrospective study
por: Yang, Huan, et al.
Publicado: (2021)

Cancer Cell-Intrinsic Alterations Associated with an Immunosuppressive Tumor Microenvironment and Resistance to Immunotherapy in Lung Cancer
por: Otegui, Nerea, et al.
Publicado: (2023)

IKKα-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines
por: Song, Na-Young, et al.
Publicado: (2022)

Immune Infiltration Landscape in Lung Squamous Cell Carcinoma Implications
por: Zhao, Jungang, et al.
Publicado: (2020)

Dominant immunosuppression of dendritic cell function by prostate-cancer-derived exosomes
por: Salimu, Josephine, et al.
Publicado: (2017)

Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma
por: Sun, Yujuan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_4nofosuepb4ov1l6krc0fsffm8