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Development of a multi-route physiologically based pharmacokinetic (PBPK) model for nanomaterials: a comparison between a traditional versus a new route-specific approach using gold nanoparticles in rats

BACKGROUND: Physiologically based pharmacokinetic (PBPK) modeling is an important tool in predicting target organ dosimetry and risk assessment of nanoparticles (NPs). The methodology of building a multi-route PBPK model for NPs has not been established, nor systematically evaluated. In this study,...

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Detalles Bibliográficos
Autores principales:	Chou, Wei-Chun, Cheng, Yi-Hsien, Riviere, Jim E., Monteiro-Riviere, Nancy A., Kreyling, Wolfgang G., Lin, Zhoumeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264615/ https://www.ncbi.nlm.nih.gov/pubmed/35804418 http://dx.doi.org/10.1186/s12989-022-00489-4

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