The immunometabolite S-2-hydroxyglutarate exacerbates perioperative ischemic brain injury and cognitive dysfunction by enhancing CD8(+) T lymphocyte-mediated neurotoxicity

BACKGROUND: Metabolic dysregulation and disruption of immune homeostasis have been widely associated with perioperative complications including perioperative ischemic stroke. Although immunometabolite S-2-hydroxyglutarate (S-2HG) is an emerging regulator of immune cells and thus triggers the immune...

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Detalles Bibliográficos
Autores principales: Zhang, Faqiang, Niu, Mu, Guo, Kaikai, Ma, Yulong, Fu, Qiang, Liu, Yanhong, Feng, Zeguo, Mi, Weidong, Wang, Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264651/
https://www.ncbi.nlm.nih.gov/pubmed/35799259
http://dx.doi.org/10.1186/s12974-022-02537-4

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