3-Bromo-Isoxazoline Derivatives Inhibit GAPDH Enzyme in PDAC Cells Triggering Autophagy and Apoptotic Cell Death

SIMPLE SUMMARY: Cancer cells largely use glycolysis to obtain both chemical energy (ATP) and metabolic intermediates for anabolic reactions, and several studies proved that the blockage of the glycolytic pathway is an efficient anticancer strategy. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a...

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Detalles Bibliográficos
Autores principales: Pacchiana, Raffaella, Mullappilly, Nidula, Pinto, Andrea, Bova, Stefania, Forciniti, Stefania, Cullia, Gregorio, Dalla Pozza, Elisa, Bottani, Emanuela, Decimo, Ilaria, Dando, Ilaria, Bruno, Stefano, Conti, Paola, Donadelli, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264795/
https://www.ncbi.nlm.nih.gov/pubmed/35804925
http://dx.doi.org/10.3390/cancers14133153

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