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AF8c, a Multi-Kinase Inhibitor Induces Apoptosis by Activating DR5/Nrf2 via ROS in Colorectal Cancer Cells

SIMPLE SUMMARY: AF8c, a lapatinib hybrid quinazoline-based EGFR/HER2 inhibitor, was chosen to scrutinize its antiproliferative activity in colorectal cancer (CRC) cells. We found that AF8cinduced apoptosis in CRC cells via diverse mechanisms. In addition to inhibiting the phosphorylation of the ErbB...

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Detalles Bibliográficos
Autores principales:	Jeong, Soyeon, Farag, Ahmed K., Yun, Hye Kyeong, Jeong, Yoon A., Kim, Dae Yeong, Jo, Min Jee, Park, Seong Hye, Kim, Bo Ram, Kim, Jung Lim, Kim, Bu Gyeom, Lee, Dae-Hee, Roh, Eun Joo, Oh, Sang Cheul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264837/ https://www.ncbi.nlm.nih.gov/pubmed/35804815 http://dx.doi.org/10.3390/cancers14133043

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