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Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018

SIMPLE SUMMARY: Primary liver cancer is currently the sixth most common cancer and the third common cause of cancer-related mortality worldwide. Incidences have increased in recent year, especially in high-income countries. The epidemiology of predisposing risk factors for hepatobiliary carcinomas h...

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Autores principales: Hucke, Florian, Pinter, Matthias, Hucke, Miriam, Bota, Simona, Bolf, Dajana, Hackl, Monika, Peck-Radosavljevic, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264900/
https://www.ncbi.nlm.nih.gov/pubmed/35804861
http://dx.doi.org/10.3390/cancers14133093
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author Hucke, Florian
Pinter, Matthias
Hucke, Miriam
Bota, Simona
Bolf, Dajana
Hackl, Monika
Peck-Radosavljevic, Markus
author_facet Hucke, Florian
Pinter, Matthias
Hucke, Miriam
Bota, Simona
Bolf, Dajana
Hackl, Monika
Peck-Radosavljevic, Markus
author_sort Hucke, Florian
collection PubMed
description SIMPLE SUMMARY: Primary liver cancer is currently the sixth most common cancer and the third common cause of cancer-related mortality worldwide. Incidences have increased in recent year, especially in high-income countries. The epidemiology of predisposing risk factors for hepatobiliary carcinomas have changed significantly, while treatment and therapeutic options have markedly improved. Here, we provide an update of incidence, mortality, and survival trends in recent years, in Austria. While age-adjusted incidence rates remained stable in almost all hepatobiliary carcinoma subtypes—except for gall-bladder cancer—the overall survival improved significantly. ABSTRACT: Using national registries, we investigated the epidemiological trends of hepatobiliary carcinomas in Austria between 2010 and 2018 and compared them to those reported for the periods of 1990–1999 and 2000–2009. In total, 12,577 patients diagnosed with hepatocellular carcinoma (n = 7146), intrahepatic cholangiocarcinoma (n = 1858), extrahepatic cholangiocarcinoma (n = 1649), gallbladder carcinoma (n = 1365), and ampullary carcinoma (n = 559), between 2010 and 2018, were included. The median overall survival of all patients was 9.0 months. The best median overall survival was observed in patients with ampullary carcinoma (28.5 months) and the worst median overall survival was observed in patients with intrahepatic carcinoma (5.6 months). The overall survival significantly improved in all entities over the period 2010–2018 as compared with over the periods of 2000–2009 and 1990–1999. Age-adjusted incidence and mortality rates remained stable for most entities in both, men and women; only in gallbladder carcinoma, the incidence and mortality rates significantly decreased in women, whereas, in men, the incidence rates remained stable and mortality rates showed a decreasing trend. We showed that age-adjusted incidence and mortality rates were stable in most entities, except in gallbladder carcinoma. The overall survival improved in almost all entities as compared with those during 1990–2009.
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spelling pubmed-92649002022-07-09 Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018 Hucke, Florian Pinter, Matthias Hucke, Miriam Bota, Simona Bolf, Dajana Hackl, Monika Peck-Radosavljevic, Markus Cancers (Basel) Article SIMPLE SUMMARY: Primary liver cancer is currently the sixth most common cancer and the third common cause of cancer-related mortality worldwide. Incidences have increased in recent year, especially in high-income countries. The epidemiology of predisposing risk factors for hepatobiliary carcinomas have changed significantly, while treatment and therapeutic options have markedly improved. Here, we provide an update of incidence, mortality, and survival trends in recent years, in Austria. While age-adjusted incidence rates remained stable in almost all hepatobiliary carcinoma subtypes—except for gall-bladder cancer—the overall survival improved significantly. ABSTRACT: Using national registries, we investigated the epidemiological trends of hepatobiliary carcinomas in Austria between 2010 and 2018 and compared them to those reported for the periods of 1990–1999 and 2000–2009. In total, 12,577 patients diagnosed with hepatocellular carcinoma (n = 7146), intrahepatic cholangiocarcinoma (n = 1858), extrahepatic cholangiocarcinoma (n = 1649), gallbladder carcinoma (n = 1365), and ampullary carcinoma (n = 559), between 2010 and 2018, were included. The median overall survival of all patients was 9.0 months. The best median overall survival was observed in patients with ampullary carcinoma (28.5 months) and the worst median overall survival was observed in patients with intrahepatic carcinoma (5.6 months). The overall survival significantly improved in all entities over the period 2010–2018 as compared with over the periods of 2000–2009 and 1990–1999. Age-adjusted incidence and mortality rates remained stable for most entities in both, men and women; only in gallbladder carcinoma, the incidence and mortality rates significantly decreased in women, whereas, in men, the incidence rates remained stable and mortality rates showed a decreasing trend. We showed that age-adjusted incidence and mortality rates were stable in most entities, except in gallbladder carcinoma. The overall survival improved in almost all entities as compared with those during 1990–2009. MDPI 2022-06-23 /pmc/articles/PMC9264900/ /pubmed/35804861 http://dx.doi.org/10.3390/cancers14133093 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hucke, Florian
Pinter, Matthias
Hucke, Miriam
Bota, Simona
Bolf, Dajana
Hackl, Monika
Peck-Radosavljevic, Markus
Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018
title Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018
title_full Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018
title_fullStr Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018
title_full_unstemmed Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018
title_short Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018
title_sort changing epidemiological trends of hepatobiliary carcinomas in austria 2010–2018
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264900/
https://www.ncbi.nlm.nih.gov/pubmed/35804861
http://dx.doi.org/10.3390/cancers14133093
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