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Identifying Lethal Dependencies with HUGE Predictive Power

SIMPLE SUMMARY: This work shows that the predictions of lethal dependencies (LEDs) between genes can be dramatically improved by incorporating the “HUb effect in Genetic Essentiality” (HUGE) of gene alterations. In three genome-wide loss-of-function screens—Project Score, CERES score and DEMETER sco...

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Detalles Bibliográficos
Autores principales:	Gimeno, Marian, San José-Enériz, Edurne, Rubio, Angel, Garate, Leire, Miranda, Estíbaliz, Castilla, Carlos, Agirre, Xabier, Prosper, Felipe, Carazo, Fernando
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264916/ https://www.ncbi.nlm.nih.gov/pubmed/35805023 http://dx.doi.org/10.3390/cancers14133251

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