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Pragmatic Expectancy on Microbiota and Non-Small Cell Lung Cancer: A Narrative Review
SIMPLE SUMMARY: Growing evidence suggests that the microbiota—or better, the changes in microbiota composition and characteristics—plays a role in lung cancer onset and is associated with each phase of tumor progression. A relevant amount of data are now available and under investigation regarding t...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264919/ https://www.ncbi.nlm.nih.gov/pubmed/35804901 http://dx.doi.org/10.3390/cancers14133131 |
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author | Stella, Giulia Maria Scialò, Filippo Bortolotto, Chandra Agustoni, Francesco Sanci, Vincenzo Saddi, Jessica Casali, Lucio Corsico, Angelo Guido Bianco, Andrea |
author_facet | Stella, Giulia Maria Scialò, Filippo Bortolotto, Chandra Agustoni, Francesco Sanci, Vincenzo Saddi, Jessica Casali, Lucio Corsico, Angelo Guido Bianco, Andrea |
author_sort | Stella, Giulia Maria |
collection | PubMed |
description | SIMPLE SUMMARY: Growing evidence suggests that the microbiota—or better, the changes in microbiota composition and characteristics—plays a role in lung cancer onset and is associated with each phase of tumor progression. A relevant amount of data are now available and under investigation regarding the characterization of the microbiome associated with lung cancer. However, in some cases, they are redundant, and in many others, hyper specialist and technical. The goal of this review is to summarize and discuss the state of the art regarding the cross-talk between lung tumors and the microbial compartment and also to put into a clinical frame their mutual interaction and influence. This pragmatic approach will be of help for future diagnostic, therapeutic and prognostic purposes. ABSTRACT: It is well known that lung cancer relies on a number of genes aberrantly expressed because of somatic lesions. Indeed, the lungs, based on their anatomical features, are organs at a high risk of development of extremely heterogeneous tumors due to the exposure to several environmental toxic agents. In this context, the microbiome identifies the whole assemblage of microorganisms present in the lungs, as well as in distant organs, together with their structural elements and metabolites, which actively interact with normal and transformed cells. A relevant amount of data suggest that the microbiota plays a role not only in cancer disease predisposition and risk but also in its initiation and progression, with an impact on patients’ prognosis. Here, we discuss the mechanistic insights of the complex interaction between lung cancer and microbiota as a relevant component of the microenvironment, mainly focusing on novel diagnostic and therapeutic objectives. |
format | Online Article Text |
id | pubmed-9264919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92649192022-07-09 Pragmatic Expectancy on Microbiota and Non-Small Cell Lung Cancer: A Narrative Review Stella, Giulia Maria Scialò, Filippo Bortolotto, Chandra Agustoni, Francesco Sanci, Vincenzo Saddi, Jessica Casali, Lucio Corsico, Angelo Guido Bianco, Andrea Cancers (Basel) Review SIMPLE SUMMARY: Growing evidence suggests that the microbiota—or better, the changes in microbiota composition and characteristics—plays a role in lung cancer onset and is associated with each phase of tumor progression. A relevant amount of data are now available and under investigation regarding the characterization of the microbiome associated with lung cancer. However, in some cases, they are redundant, and in many others, hyper specialist and technical. The goal of this review is to summarize and discuss the state of the art regarding the cross-talk between lung tumors and the microbial compartment and also to put into a clinical frame their mutual interaction and influence. This pragmatic approach will be of help for future diagnostic, therapeutic and prognostic purposes. ABSTRACT: It is well known that lung cancer relies on a number of genes aberrantly expressed because of somatic lesions. Indeed, the lungs, based on their anatomical features, are organs at a high risk of development of extremely heterogeneous tumors due to the exposure to several environmental toxic agents. In this context, the microbiome identifies the whole assemblage of microorganisms present in the lungs, as well as in distant organs, together with their structural elements and metabolites, which actively interact with normal and transformed cells. A relevant amount of data suggest that the microbiota plays a role not only in cancer disease predisposition and risk but also in its initiation and progression, with an impact on patients’ prognosis. Here, we discuss the mechanistic insights of the complex interaction between lung cancer and microbiota as a relevant component of the microenvironment, mainly focusing on novel diagnostic and therapeutic objectives. MDPI 2022-06-26 /pmc/articles/PMC9264919/ /pubmed/35804901 http://dx.doi.org/10.3390/cancers14133131 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Stella, Giulia Maria Scialò, Filippo Bortolotto, Chandra Agustoni, Francesco Sanci, Vincenzo Saddi, Jessica Casali, Lucio Corsico, Angelo Guido Bianco, Andrea Pragmatic Expectancy on Microbiota and Non-Small Cell Lung Cancer: A Narrative Review |
title | Pragmatic Expectancy on Microbiota and Non-Small Cell Lung Cancer: A Narrative Review |
title_full | Pragmatic Expectancy on Microbiota and Non-Small Cell Lung Cancer: A Narrative Review |
title_fullStr | Pragmatic Expectancy on Microbiota and Non-Small Cell Lung Cancer: A Narrative Review |
title_full_unstemmed | Pragmatic Expectancy on Microbiota and Non-Small Cell Lung Cancer: A Narrative Review |
title_short | Pragmatic Expectancy on Microbiota and Non-Small Cell Lung Cancer: A Narrative Review |
title_sort | pragmatic expectancy on microbiota and non-small cell lung cancer: a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264919/ https://www.ncbi.nlm.nih.gov/pubmed/35804901 http://dx.doi.org/10.3390/cancers14133131 |
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