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Risk Factors and Clinicopathological Features for Developing a Subsequent Primary Cutaneous Squamous and Basal Cell Carcinomas

SIMPLE SUMMARY: Patients with basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC) often develop new keratinocyte carcinoma (KC), but information is limited on the frequency and timing of these subsequent tumors. This information is crucial to guide follow-up care. Given the signif...

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Autores principales: Ciążyńska, Magdalena, Pabianek, Marta, Sławińska, Martyna, Reich, Adam, Lewandowski, Bogumił, Szczepaniak, Katarzyna, Ułańska, Małgorzata, Nejc, Dariusz, Brodowski, Robert, Sobjanek, Michał, Owczarek, Witold, Kamińska-Winciorek, Grażyna, Lange, Dariusz, Słowińska, Monika, Wróbel, Katarzyna, Bieniek, Andrzej, Woźniacka, Anna, Pękala, Anika, Kuncman, Łukasz, Salińska, Magdalena, Noweta, Marcin, Skibińska, Małgorzata, Narbutt, Joanna, Ciążyński, Karol, Lewandowska, Marta, Dziankowska-Zaborszczyk, Elżbieta, Lesiak, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264931/
https://www.ncbi.nlm.nih.gov/pubmed/35804841
http://dx.doi.org/10.3390/cancers14133069
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author Ciążyńska, Magdalena
Pabianek, Marta
Sławińska, Martyna
Reich, Adam
Lewandowski, Bogumił
Szczepaniak, Katarzyna
Ułańska, Małgorzata
Nejc, Dariusz
Brodowski, Robert
Sobjanek, Michał
Owczarek, Witold
Kamińska-Winciorek, Grażyna
Lange, Dariusz
Słowińska, Monika
Wróbel, Katarzyna
Bieniek, Andrzej
Woźniacka, Anna
Pękala, Anika
Kuncman, Łukasz
Salińska, Magdalena
Noweta, Marcin
Skibińska, Małgorzata
Narbutt, Joanna
Ciążyński, Karol
Lewandowska, Marta
Dziankowska-Zaborszczyk, Elżbieta
Lesiak, Aleksandra
author_facet Ciążyńska, Magdalena
Pabianek, Marta
Sławińska, Martyna
Reich, Adam
Lewandowski, Bogumił
Szczepaniak, Katarzyna
Ułańska, Małgorzata
Nejc, Dariusz
Brodowski, Robert
Sobjanek, Michał
Owczarek, Witold
Kamińska-Winciorek, Grażyna
Lange, Dariusz
Słowińska, Monika
Wróbel, Katarzyna
Bieniek, Andrzej
Woźniacka, Anna
Pękala, Anika
Kuncman, Łukasz
Salińska, Magdalena
Noweta, Marcin
Skibińska, Małgorzata
Narbutt, Joanna
Ciążyński, Karol
Lewandowska, Marta
Dziankowska-Zaborszczyk, Elżbieta
Lesiak, Aleksandra
author_sort Ciążyńska, Magdalena
collection PubMed
description SIMPLE SUMMARY: Patients with basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC) often develop new keratinocyte carcinoma (KC), but information is limited on the frequency and timing of these subsequent tumors. This information is crucial to guide follow-up care. Given the significant clinical differences of the characteristic feature of individual skin cancer, estimation of the risk of a subsequent tumor should be estimating separately. The aim of our retrospective study was to assess risk factors for a subsequent skin cancer development. We demonstrated that patients with multiple tumors must be followed up carefully and for a long time. Moreover, we indicated the connection between the BCC subtype and increased risk for further KC development. BCC subtypes with an aggressive growth pattern predispose not only to increased risk for the recurrence but also are expected to be at an increased risk for a subsequent tumor. The non-invasive diagnosis, monitoring and follow up should be more comprehensive for those patients compared to low-risk BCC. ABSTRACT: Background: Patients with diagnosed keratinocyte carcinomas (KCs) have an increased risk of subsequent skin cancers development. Current studies indicate that patients with subsequent tumors should be followed up regularly. However, none of the studies indicate the connection between the specific subtypes and an increased risk for further KCs development. The study assesses the differences in the risk of developing a subsequent skin cancer after a previous diagnosis of KC, especially considering individual types of skin malignances, and identifies potential factors associated with an increased risk of new cutaneous tumor describing non-invasive diagnosis and monitoring. Methods: Pathology and medical records were examined to identify the characteristics of patients with multiple KCs diagnosed between 1999 and 2019. Results: The study group comprised 13,913 KCs occurring in 10,083 patients. Multiple KCs were observed in 2300 patients (22.8%). The analysis showed aggressive subtypes, multiple tumors, and male sex as significant prognostic factors. Conclusions: The most crucial risk factors for developing subsequent KC are being of a male gender, an aggressive tumor subtype, and previous history of multiple skin cancers. Basal cell carcinoma subtypes, such as infiltrative basosquamous, with aggressive growth patterns predispose not only to increased risk for the recurrence but are also expected to be at higher risk of subsequent KCs.
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spelling pubmed-92649312022-07-09 Risk Factors and Clinicopathological Features for Developing a Subsequent Primary Cutaneous Squamous and Basal Cell Carcinomas Ciążyńska, Magdalena Pabianek, Marta Sławińska, Martyna Reich, Adam Lewandowski, Bogumił Szczepaniak, Katarzyna Ułańska, Małgorzata Nejc, Dariusz Brodowski, Robert Sobjanek, Michał Owczarek, Witold Kamińska-Winciorek, Grażyna Lange, Dariusz Słowińska, Monika Wróbel, Katarzyna Bieniek, Andrzej Woźniacka, Anna Pękala, Anika Kuncman, Łukasz Salińska, Magdalena Noweta, Marcin Skibińska, Małgorzata Narbutt, Joanna Ciążyński, Karol Lewandowska, Marta Dziankowska-Zaborszczyk, Elżbieta Lesiak, Aleksandra Cancers (Basel) Article SIMPLE SUMMARY: Patients with basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC) often develop new keratinocyte carcinoma (KC), but information is limited on the frequency and timing of these subsequent tumors. This information is crucial to guide follow-up care. Given the significant clinical differences of the characteristic feature of individual skin cancer, estimation of the risk of a subsequent tumor should be estimating separately. The aim of our retrospective study was to assess risk factors for a subsequent skin cancer development. We demonstrated that patients with multiple tumors must be followed up carefully and for a long time. Moreover, we indicated the connection between the BCC subtype and increased risk for further KC development. BCC subtypes with an aggressive growth pattern predispose not only to increased risk for the recurrence but also are expected to be at an increased risk for a subsequent tumor. The non-invasive diagnosis, monitoring and follow up should be more comprehensive for those patients compared to low-risk BCC. ABSTRACT: Background: Patients with diagnosed keratinocyte carcinomas (KCs) have an increased risk of subsequent skin cancers development. Current studies indicate that patients with subsequent tumors should be followed up regularly. However, none of the studies indicate the connection between the specific subtypes and an increased risk for further KCs development. The study assesses the differences in the risk of developing a subsequent skin cancer after a previous diagnosis of KC, especially considering individual types of skin malignances, and identifies potential factors associated with an increased risk of new cutaneous tumor describing non-invasive diagnosis and monitoring. Methods: Pathology and medical records were examined to identify the characteristics of patients with multiple KCs diagnosed between 1999 and 2019. Results: The study group comprised 13,913 KCs occurring in 10,083 patients. Multiple KCs were observed in 2300 patients (22.8%). The analysis showed aggressive subtypes, multiple tumors, and male sex as significant prognostic factors. Conclusions: The most crucial risk factors for developing subsequent KC are being of a male gender, an aggressive tumor subtype, and previous history of multiple skin cancers. Basal cell carcinoma subtypes, such as infiltrative basosquamous, with aggressive growth patterns predispose not only to increased risk for the recurrence but are also expected to be at higher risk of subsequent KCs. MDPI 2022-06-23 /pmc/articles/PMC9264931/ /pubmed/35804841 http://dx.doi.org/10.3390/cancers14133069 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ciążyńska, Magdalena
Pabianek, Marta
Sławińska, Martyna
Reich, Adam
Lewandowski, Bogumił
Szczepaniak, Katarzyna
Ułańska, Małgorzata
Nejc, Dariusz
Brodowski, Robert
Sobjanek, Michał
Owczarek, Witold
Kamińska-Winciorek, Grażyna
Lange, Dariusz
Słowińska, Monika
Wróbel, Katarzyna
Bieniek, Andrzej
Woźniacka, Anna
Pękala, Anika
Kuncman, Łukasz
Salińska, Magdalena
Noweta, Marcin
Skibińska, Małgorzata
Narbutt, Joanna
Ciążyński, Karol
Lewandowska, Marta
Dziankowska-Zaborszczyk, Elżbieta
Lesiak, Aleksandra
Risk Factors and Clinicopathological Features for Developing a Subsequent Primary Cutaneous Squamous and Basal Cell Carcinomas
title Risk Factors and Clinicopathological Features for Developing a Subsequent Primary Cutaneous Squamous and Basal Cell Carcinomas
title_full Risk Factors and Clinicopathological Features for Developing a Subsequent Primary Cutaneous Squamous and Basal Cell Carcinomas
title_fullStr Risk Factors and Clinicopathological Features for Developing a Subsequent Primary Cutaneous Squamous and Basal Cell Carcinomas
title_full_unstemmed Risk Factors and Clinicopathological Features for Developing a Subsequent Primary Cutaneous Squamous and Basal Cell Carcinomas
title_short Risk Factors and Clinicopathological Features for Developing a Subsequent Primary Cutaneous Squamous and Basal Cell Carcinomas
title_sort risk factors and clinicopathological features for developing a subsequent primary cutaneous squamous and basal cell carcinomas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264931/
https://www.ncbi.nlm.nih.gov/pubmed/35804841
http://dx.doi.org/10.3390/cancers14133069
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