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Cordycepin (3′-Deoxyadenosine) Suppresses Heat Shock Protein 90 Function and Targets Tumor Growth in an Adenosine Deaminase-Dependent Manner

SIMPLE SUMMARY: Our study contributes to understanding the therapeutic effects of cordycepin in cancer. First, we find that the anticancer effects of cordycepin alone are only seen in tumor cell lines with low ADA expression or activity. This was true in multiple tumor types and may be applied as a...

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Detalles Bibliográficos
Autores principales: Lee, Su-Chan, Alaali, Lujain, Kwon, HyukJean, Rigi, Mohammed, Eberhart, Charles G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9264932/
https://www.ncbi.nlm.nih.gov/pubmed/35804893
http://dx.doi.org/10.3390/cancers14133122